Articles: analgesics.
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Ugeskrift for laeger · Dec 1993
Randomized Controlled Trial Clinical Trial[Analgesic effect of 2 different doses of intra-articular morphine after ambulatory knee arthroscopy. A randomized, prospective, double-blind study].
The effect of intra-articular morphine following knee arthroscopy has been verified in several studies, but the optimal dose has not been established. An earlier study by the authors showed significant effect of one mg morphine versus placebo. In this study, fifty patients were randomized to receive either two or four mg of intra-articular morphine following day-case knee arthroscopy in infiltration analgesia. ⋯ The results showed no significant difference in VAS score between the two dose regimes at any time. Onset of pain after cessation of the local analgesia was not influenced by the morphine dose. On this basis it is recommended to limit the dose of intraarticular morphine, as local adverse reactions to morphine cannot be ruled out.
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Ugeskrift for laeger · Dec 1993
Randomized Controlled Trial Clinical Trial[Analgesic effect of low-dose intra-articular morphine after ambulatory knee arthroscopy].
The purpose of this study was to demonstrate the effect of intra-articular morphine following knee arthroscopy performed in infiltration analgesia. Fifty-two healthy patients were randomized to receive either morphine 1 mg or placebo. The pain was assessed two, five, eight and 24 hours after the procedure by 1) a VAS scale and 2) the amount of acetaminophen consumed. ⋯ Stratifying data in therapeutic vs. diagnostic arthroscopy suggests an additional effect of morphine in patients undergoing therapy (0.05 < p < 0.10), an aspect which supports the hypothesis of peripherally administered morphine acting as a potential suppressor of the substance P mediated cytokine cascade. Intraarticular morphine 1 mg after knee arthroscopy offers efficient analgesia lasting more than 24 hours. The method is devoid of side effects and deserves wider recognition.
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Anxieties and emotional disturbances associated with cancer often cause pain therapy to be unsuccessful. When psychological support is required it is mostly aimed at supporting cancer patients in attempts to cope with their disease so as to improve the efficiency of pain therapy. In our study we focused on the barriers to cancer pain management that lie in patient's beliefs about pain and their coping behavior. ⋯ Those patients who used cognitive coping strategies and did not communicate often received inadequate pain therapy. Those who talked about pain but did not use any other coping strategies were mostly well treated. We have designed a brochure, "What tumour patients should know about pain" directly oriented on the above pain beliefs; this is now being evaluated with reference to its educational effect.
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Review Comparative Study
Do antidepressant medications relieve chronic low back pain?
Antidepressant medications are commonly prescribed for patients with chronic low back pain. A literature synthesis was performed to determine whether antidepressants are more effective than placebos in decreasing pain, disability, depression, and analgesic medication use in such patients. ⋯ The literature has not demonstrated that antidepressants are superior to placebos in improving low back pain or related problems. However, further randomized controlled trials are needed to determine whether antidepressants are useful for low back pain.