Articles: analgesics.
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It is reported that intrathecal (it) injection of low dose of dynorphin (Dyn) induces no analgesia while high dose of Dyn induces analgesia and might lead to hindlimb paralysis and loss of reflex via NMDA receptor. We hypothesized that NMDA receptor antagonists may reveal kappa analgesic-potential of subliminal dose of Dyn. ⋯ Combination of Dyn A- (1-13) 5 nmol or U50488H 100 nmol, a kappa receptor agonist with either DL-2-amino-5-phosphonovaleric acid (5 and 10 nmol) or kynurenic acid (25 and 50 nmol) it induced synergistic analgesia, which was reversed by nor-binaltorphimine 15 nmol, a kappa receptor antagonist. It is concluded that kappa opioid receptor agonists and NMDA receptor antagonists synergistically induce analgesia via interaction with their receptors.
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Ugeskrift for laeger · Dec 1993
Randomized Controlled Trial Clinical Trial[Analgesic effect of 2 different doses of intra-articular morphine after ambulatory knee arthroscopy. A randomized, prospective, double-blind study].
The effect of intra-articular morphine following knee arthroscopy has been verified in several studies, but the optimal dose has not been established. An earlier study by the authors showed significant effect of one mg morphine versus placebo. In this study, fifty patients were randomized to receive either two or four mg of intra-articular morphine following day-case knee arthroscopy in infiltration analgesia. ⋯ The results showed no significant difference in VAS score between the two dose regimes at any time. Onset of pain after cessation of the local analgesia was not influenced by the morphine dose. On this basis it is recommended to limit the dose of intraarticular morphine, as local adverse reactions to morphine cannot be ruled out.