Articles: nifurtimox-therapeutic-use.
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Nifurtimox therapeutic use
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Cochrane Db Syst Rev · Dec 2020
Review Meta AnalysisTrypanocidal drugs for late-stage, symptomatic Chagas disease (Trypanosoma cruzi infection).
People with Chagas disease may develop progressive and lethal heart conditions. Drugs to eliminate the parasite Trypanosoma cruzi (T cruzi) currently carry limited therapeutic value and are used in the early stages of the disease. Extending the use of these drugs to treat chronic chagasic cardiomyopathy (CCC) has also been proposed. ⋯ There is insufficient evidence to support the efficacy of the trypanocidal drugs benznidazole and nifurtimox for late-stage, symptomatic Chagas disease and CCC.