Articles: adult.
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Adult
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Journal of anesthesia · Dec 2014
Dexmedetomidine suppresses long-term potentiation in the hippocampal CA1 field of anesthetized rats.
The aim of this study was to evaluate the effect of dexmedetomidine (DEX) on hippocampal synaptic activity in vivo. ⋯ The results of our in vivo study reveal that sedative doses of DEX impaired the induction of hippocampal long-term potentiation (LTP). These findings may signify a causal link between DEX-induced sedative action and hippocampal LTP suppression, providing a better understanding of the mechanisms underlying the DEX-induced sedative and/or amnestic effect.