Articles: pandemics.
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Salud pública de México · Jan 2013
The impact of altitude on hospitalization and hospital mortality from pandemic 2009 influenza A (H1N1) virus pneumonia in Mexico.
To determine the effect of altitude of residence on influenza A (H1N1). ⋯ Adjusted rates for hospitalization and hospital mortality rates increased with altitude, probably due to hypoxemia.
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The pandemic H1N1 influenza that began in Mexico in the spring of 2009 spread rapidly to southern California within days and around the world within a few months. Because the genetic make-up of the new virus was novel, several months of lead-in time were required before a suitable vaccine for human use could be produced and distributed. ⋯ Because of the extensive publicity and research that occurred during the H1N1 pandemic, many lessons were learned that will be useful in confronting future influenza pandemics. A "One Health" approach to prevent, detect, and combat future pandemics is essential.
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The clinical consequences of co-infection with two or more respiratory viruses are poorly understood. We sought to determine if co-infection with pandemic 2009-2010 influenza A H1N1 (pH1N1) and another respiratory virus was associated with worse clinical outcomes. ⋯ Patients with viral co-infection, particularly with pH1N1, were more likely to have chest radiograph features compatible with a viral pneumonia and complications during their hospital course, particularly treatment for secondary bacterial pneumonia. Despite this, co-infection was not associated with ICU admission.