Articles: erectile-dysfunction.
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Randomized Controlled Trial Multicenter Study Comparative Study
Hemodynamic effects of sildenafil citrate and isosorbide mononitrate in men with coronary artery disease and erectile dysfunction.
Mild hemodynamic effects have been reported with sildenafil citrate therapy. ⋯ Sildenafil 100 mg was well tolerated and induced smaller changes in central and peripheral hemodynamic pressures compared with ISMN 40 mg. Moreover, sildenafil selectively reduced pulmonary resistance, which may have clinical importance in pulmonary hypertension.
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomised controlled trial of pelvic floor muscle exercises and manometric biofeedback for erectile dysfunction.
The pelvic floor muscles are active in normal erectile function. Therefore, it was hypothesised that weak pelvic floor muscles could be a cause of erectile dysfunction. ⋯ Pelvic floor muscle exercises and biofeedback are an effective treatment for men with erectile dysfunction.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Efficacy and safety of tadalafil in a Western European population of men with erectile dysfunction.
To evaluate, in a randomized, double-blind, placebo-controlled, multicentre trial, the safety and efficacy of on-demand tadalafil (an oral phosphodiesterase type-5 inhibitor approved in many countries for treating erectile dysfunction, ED) in a Western European population of men with mild-to-severe ED. ⋯ Tadalafil improved erectile function and was well tolerated when taken by men from Western Europe with mild-to-severe ED.
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Randomized Controlled Trial Multicenter Study
Efficacy and safety of on-demand oral tadalafil in the treatment of men with erectile dysfunction in Taiwan: a randomized, double-blind, parallel, placebo-controlled clinical study.
Tadalafil is a phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction (ED). Past clinical trials have assessed its efficacy and safety in western populations. Tadalafil has not been investigated in a large clinical trial with a South-east Asian population. ⋯ Tadalafil was an effective, well-tolerated therapy for men in Taiwan with ED of broad-spectrum severity and etiology.
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Randomized Controlled Trial Clinical Trial
Acceptability of short term neo-adjuvant androgen deprivation in patients with locally advanced prostate cancer.
To determine the acceptability of short term neo-adjuvant maximal androgen deprivation (MAD) to patients treated with external beam radiation for locally advanced prostate cancer. ⋯ Despite temporary effects on sexual activity, and compliance difficulties with flutamide, short-term neo-adjuvant MAD was not perceived by patients to be a major inconvenience. If neo-adjuvant MAD in the way tested can be demonstrated to lead to improved biochemical control and/or survival, then patients would view these therapeutic gains as worthwhile. Compliance with short-term goserelin was excellent, confirming that LH-RH analogues have a potential role in more long-term adjuvant treatment. However, for more protracted androgen deprivation, survival advantages and deleterious effects need to be assessed in parallel, in order to determine the optimal duration of treatment.