Articles: child.
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Randomized Controlled Trial Multicenter Study Comparative Study
Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children.
Children with human immunodeficiency virus type 1 (HIV-1) infection have limited options for effective antiretroviral treatment (ART). ⋯ In this trial involving children and adolescents with HIV-1 infection who were starting first- or second-line treatment, dolutegravir-based ART was superior to standard care. (Funded by ViiV Healthcare; ODYSSEY ClinicalTrials.gov number, NCT02259127; EUDRACT number, 2014-002632-14; and ISRCTN number, ISRCTN91737921.).
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Randomized Controlled Trial
A Pilot Randomized Controlled Trial of Virtual Reality Distraction to Reduce Procedural Pain During Subcutaneous Port Access in Children with Cancer.
We aimed to determine the feasibility of virtual reality (VR) distraction for children with cancer undergoing subcutaneous port (SCP) access. We also aimed to estimate preliminary treatment effects of VR compared with an active distraction control (iPad). ⋯ VR was feasible and acceptable to implement as an intervention during SCP access. Preliminary effectiveness results indicate that VR may reduce distress and distress compared with iPad distraction. These data will inform design of a future full-scale randomized controlled trial.
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Randomized Controlled Trial
Improving knowledge and perception of HIV/AIDS among English language speaking children in rural areas through educational digital storytelling.
Previous research efforts have shown the need for improvement of knowledge and perception of HIV/AIDS among English Language speaking children in rural areas. Hence, the study at hand was designed to investigate the effect of using educational digital storytelling intervention to satisfy this need of English Language children in rural areas in Nigeria. ⋯ The present study showed that the use of educational digital storytelling could improve knowledge and perception of HIV/AIDS among English Language speaking children in rural areas. Educational digital storytelling intervention effectively improved knowledge and perception of HIV/AIDS among children in rural areas. In return, we recommend that rural sociologists, counselors, language and communication experts, child educators, and other professionals involved in public health especially, as it concerns children be skilled in the use and application of educational digital storytelling intervention procedures to facilitate the move towards adopting the method in their professional practices.
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Randomized Controlled Trial Multicenter Study
Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma.
Children with moderate-to-severe asthma continue to have disease complications despite the receipt of standard-of-care therapy. The monoclonal antibody dupilumab has been approved for the treatment of adults and adolescents with asthma as well as with other type 2 inflammatory diseases. ⋯ Among children with uncontrolled moderate-to-severe asthma, those who received add-on dupilumab had fewer asthma exacerbations and better lung function and asthma control than those who received placebo. (Funded by Sanofi and Regeneron Pharmaceuticals; Liberty Asthma VOYAGE ClinicalTrials.gov number, NCT02948959.).
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Int. J. Clin. Pract. · Dec 2021
Randomized Controlled TrialThe Effect of Online Solution-Focused Brief Therapy on Parents with High Level of Anxiety in the COVID 19 Pandemic: A Randomized Controlled Study.
The aim of this study was to determine the anxiety levels of parents with children aged 3-6 years because of the Coronavirus Disease 2019 (COVID-19) pandemic and to examine the effects of Solution-Focused Support Program (SFSP) applied to parents with a high level of anxiety. ⋯ In the study, it has been found that SFSP applied to parents with a high level of anxiety is an effective method in reducing the state anxiety levels of parents.