International journal of clinical practice
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Int. J. Clin. Pract. · Dec 2021
Multicenter StudyObesity is associated with a greater number of long-term post-COVID symptoms and poor sleep quality: A multicentre case-control study.
Obesity is a risk factor associated with higher mortality at the acute phase of COVID-19; however, its influence on post-COVID symptoms is not known. ⋯ This study found that obesity was associated with a greater number of long-term post-COVID symptoms and poor sleep quality in hospitalised COVID-19 patients.
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Int. J. Clin. Pract. · Dec 2021
Randomized Controlled TrialCan zirconia crowns be the first restorative choice after endodontic treatment of primary teeth?
Early loss of primary teeth due to caries can cause temporary or permanent problems, such as occlusion disorders, aesthetic problems, nutritional problems, abnormal habits, and speech disorders. Although the development of restorative materials has led to significant improvements, failures are still frequent. The purpose of this study was to evaluate the success rates of zirconia crowns compared to other crowns for the restoration of endodontically treated teeth with excessive loss of material. ⋯ The clinical outcomes of ZCs were comparable to those of the other crowns. ZCs could be a choice for aesthetic purposes, with the disadvantage of a higher cost.
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Int. J. Clin. Pract. · Dec 2021
ReviewA systematic review of cases of West African Crystalline Maculopathy.
West African crystalline maculopathy (WACM) is, reportedly, a rare condition whose aetiology remains unclear. This study aims to describe the epidemiology, summarizing the identified risk factors and clinical characteristics of cases of WACM, with the goal of highlighting presentation patterns and the clinical course of the condition. ⋯ West African crystalline retinopathy is a seemingly innocuous condition affecting black or African people, who were also born in Africa. The majority of the patients have a vascular retinopathy. Longitudinal studies, particularly in Africa, may be required to elucidate the aetiology, as well as the long-term prognosis, of the crystals.
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Int. J. Clin. Pract. · Dec 2021
Meta AnalysisTotal and drinking water intake and risk of all-cause and cardiovascular mortality: a systematic review and dose-response meta-analysis of prospective cohort studies.
Understanding the association between water consumption and mortality is important for guiding consumers and prioritizing dietary guidelines to reduce the risk. Therefore, in the current study, we conducted a systematic review and dose-response meta-analysis of prospective cohort studies to summarise the association between total water and drinking intake and risk of mortality from all causes and CVD. ⋯ High consumption of total water is associated with a lower risk of CVD mortality. However, total water intake was not associated with risk of all-cause mortality.
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Int. J. Clin. Pract. · Dec 2021
Multicenter StudySafety and efficacy of alirocumab in real life setting: analysis of the Belgian cohort of the ODYSSEY APPRISE trial with review of current lipid treatment guidelines and its implementation in clinical practice.
As lipid targets became more stringent in the latest ESC/EAS guidelines, many patients on statin monotherapy are left above their risk-based target, increasing the need for lipid-lowering therapies. The results of the ODYSSEY APPRISE study were recently published by Gaudet et al In this trial, alirocumab (a PCSK9 inhibitor) was investigated in high cardiovascular risk patients in a real-life setting. ⋯ In a real-life setting, alirocumab is both well-tolerated, safe and very effective in reducing LDL-c in this Belgian cohort. In clinical practice, more patients should be initiated on the add-on, non-statin lipid-lowering therapy in order to reach their risk-based lipid target.