Articles: postoperative-pain.
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To study the common methods of analgesia and their effectiveness in post-operative patients and to assess the occurrence of common post-operative complications related to pain. ⋯ The results suggest that the standard of post-operative pain relief is poor. Patients need to be told more about what to expect (and demand). The medical and nursing staff need further education in how to prescribe and administer analgesia with reference to individual drug response. Other more effective methods of pain control should be introduced.
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Although outpatient surgery shortens hospital stays, patients still experience anxiety and pain. Encourage nurses to maximize their communication skills and focus on pain management.
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MPV-2426 is a novel alpha2-adrenoceptor agonist developed for spinal pain therapy. It has proved to be effective in physiologic and neuropathic conditions. In the current study its effectiveness on mechanical hyperalgesia was assessed in a rat model of postoperative pain. ⋯ Intrathecal MPV-2426 dose-dependently attenuates postoperative hyperalgesia to mechanical stimulation because of an action on alpha2 adrenoceptors. Its antihyperalgesic action is as effective as that produced by dexmedetomidine and is considerably stronger than that produced by clonidine. However, preoperative treatment with MPV-2426 does not prevent the development of postoperative hyperalgesia.