Articles: low-back-pain.
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Curr Pain Headache Rep · Oct 2007
ReviewTreatment of chronic low back pain with botulinum neurotoxins.
In a double-blind, randomized, placebo-controlled study, administration of botulinum toxin A (Botox; Allergan Inc., Irvine, CA) into paraspinal muscles using a novel technique produced significant pain relief in 60% of patients with chronic, refractory low back pain. A similar yield of 53% was noted in a prospective, randomized, open-label study of 75 patients, with 14 months of follow-up. In this study, an early response predicted later responsiveness, with 91% of the responders continuing to respond to repeat injections. ⋯ The dose per injection site was 50 U (Botox), with the total dose per session not to exceed 500 U. Side effects were uncommon and consisted of a transient, mild flu-like reaction in 5% of the patients. Botulinum treatment of paraspinal muscles can reduce pain in a substantial number of patients with refractory chronic low back pain and is safe in the recommended doses.
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Multicenter Study
[Percutaneous discectomy and intradiscal radiofrequency thermocoagulation for low back pain: evaluation according to the best available evidence].
Within the framework of evidence-based medicine, high quality randomized trials and systematic reviews are needed for new medical treatment. Clinicians should conscientiously, explicitly and judiciously use the best current evidence in making decisions about the care of individual patients. This paper summarizes the best available evidence from systematic reviews and randomized controlled trials concerning two minimally invasive procedures: percutaneous discectomy and percutaneous intradiscal radiofrequency thermocoagulation. ⋯ Results of systematic reviews were retrieved from four leading evidence-based databases: the National Institute for Clinical Excellence--NICE, which is an independent organization responsible for providing national guidance on treatments, the Cochrane Library, which is the largest library world-wide for systematic reviews and randomized controlled trials, the Center for Review and Dissemination (CRD) at the University of York, which undertakes reviews of research about the effects of interventions in health and social care and finally, a search via Medline. The results from those systematic reviews and randomized trials shows that, at present, unless or until better scientific evidence is available, automated percutaneous discectomy and laser discectomy should be regarded as research techniques. Radiofrequency denervation can relieve pain from neck joints, but may not relieve pain originating from lumbar discs, and its impact on low-back joint pain is uncertain.
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Comparative Study
Disabling low back pain and depressive symptoms in the community-dwelling elderly: a prospective study.
Analytic cross-sectional and cohort study. ⋯ Among community-dwelling elderly persons, depressive symptoms and disabling LBP are widespread. Depressive symptoms predict disabling LBP and vice versa. The set of predictors and their extent of contribution to the prognosis are strikingly similar. Research is warranted to identify possible common pathogenic mechanisms or mediating factors.
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Middle East J Anaesthesiol · Oct 2007
Case ReportsIntervertebral disc a source of pain? Low back pain: problems and future directions--case reports.
The objective of this article is to provide evidence supporting the idea that intervertebral disc is a source of low back pain. ⋯ Intervertebral disc is a source of low back pain that is often ignored. No diagnostic test currently exists that can reliably confirm presence of a painful disc. Early diagnosis and treatment of a painful disc may reduce enormous pain and suffering from low back pain.
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There are few studies on minimally invasive injection therapy (MIT) combined with multimodal conservative therapeutic options. Here, we evaluate the results of MIT in a clinical study. ⋯ MIT is an effective approach with few complications for the treatment of patients with radicular syndromes.