Articles: general-anesthesia.
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Clinical Trial
The cardiovascular effects of mivacurium chloride (BW B1090U) in patients receiving nitrous oxide-opiate-barbiturate anesthesia.
The dose-effect relationship of mivacurium chloride on arterial blood pressure, heart rate, and plasma histamine was determined in 97 consenting ASA physical status I-II patients receiving nitrous oxide-oxygen-opiate-barbiturate anesthesia. In the absence of surgical stimulation during steady state anesthetic conditions with controlled ventilation, average maximum change in tachograph-counted heart rate was 7% or less after 10-15-s injection of mivacurium at all doses from 0.03 to 0.30 mg/kg. Average peak change in mean arterial pressure measured via radial arterial catheter was 7% or less after all doses from 0.03 to 0.15 mg/kg. ⋯ For example, mean blood pressure decreased an average of 13% after injection of mivacurium 0.25 mg/kg over 10-15 s. In contrast, during administration over 30 and 60 s of this dose, arterial pressure decreased 7.6 and 1.5%, respectively (P less than 0.001, 10-15 s vs. 60-s injection). Average peak histamine level, which increased to 132% of control after administration of 0.25 mg/kg over 10-15 s, did not change after injection over 60 s.(ABSTRACT TRUNCATED AT 250 WORDS)
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Anasth Intensivther Notfallmed · Feb 1989
Comparative Study[Mechanomyography and electromyography--2 competing methods of relaxometry using vecuronium].
The recording of the evoked twitch tension has been the established reference method to quantitate neuromuscular blockade. The evoked compound electromyogram has been introduced later as a clinically more convenient alternative. We compared both methods in 20 patients in whom cumulative dose response curves of vecuronium and the time constants of weaning neuromuscular blockade were determined. ⋯ No significant differences between the two methods were found in the cumulative 90% blocking dose, the duration of block and the recovery time (25%-75%). These results are in agreement with communications of previous authors using different nondepolarizing muscle relaxants. In the absence of abnormal conditions such as neuromuscular disorders and hypothermia, recording of evoked electromyography is a clinically satisfactory method to quantitate neuromuscular blockade.