Articles: general-anesthesia.
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An anaesthetic technique suitable for training in fibreoptic intubation is described. It uses a capped oropharyngeal airway which leaves the nose free for fibreoptic intubation and allows the airway to be maintained and ventilation to be controlled if necessary. An assessment is made of the technique after 50 fibreoptic intubations with the Olympus LF-1 fibrescope. There were no failed intubations and no serious complications.
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Propofol like thiopental and etomidate, suppresses cortical electrical activity in a dose-related manner, which leads to a 36% decrease in cerebral oxygen uptake and a 51% decrease in cerebral blood flow after an induction dose of 2 mg/kg followed by a maintenance dose of 0.2 mg/kg per min. In this study, the effects of propofol and varying paCO2 values on cerebral energy and amino acid metabolism were examined. METHODS. ⋯ Lactate/glucose index was calculated from the equation. Formula: see text. where a-vD lactate and a-vD glucose represent the arterial-cerebral venous substrate differences in mmol/l. Cerebral electrical activity was recorded by Fourier analysis of the EEG.(ABSTRACT TRUNCATED AT 250 WORDS)
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Randomized Controlled Trial Clinical Trial
Influence of extradural and general anaesthesia on natural killer cell activity and lymphocyte subpopulations in patients undergoing hysterectomy.
The effect of hysterectomy was studied on natural killer (NK) cell activity, the distribution of lymphocyte subpopulations, and the endocrine stress response in 16 patients allocated to receive extradural analgesia S5-T4 (group I) or neuroleptanaesthesia (NLA) (group II). In group II a significant decrease in NK cell activity was found after operation for at least 3 days, while surgery during extradural analgesia did not induce significant changes. ⋯ Compared with group II, extradural analgesia significantly reduced the cortisol and noradrenaline response to surgery, while the adrenaline response in both groups was abolished. The results suggest that the decrease in NK cell activity and alterations in lymphocyte subsets induced by surgery and general anaesthesia can be prevented to a certain degree by extradural analgesia.