Articles: chronic-pain.
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Randomized Controlled Trial Retraction Of Publication
Effect of a Long-lasting Multidisciplinary Program on Disability and Fear-Avoidance Behaviors in Patients With Chronic Low Back Pain Results of a Randomized Controlled Trial: Retraction.
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Retraction Of Publication
Retraction of: Effect of Sham Acupuncture on Chronic Pain: A Bayesian Network Meta-Analysis.
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Retracted Publication
Effect of Sham Acupuncture on Chronic Pain: A Bayesian Network Meta-analysis.
Along with increasing research on acupuncture for chronic pain, the validity of sham acupuncture (SA) has also been argued. ⋯ These results suggested that acupuncture was significantly associated with reduced chronic pain. The two kinds of placebo acupuncture, NPSA and PSA, have similar effects. Both NPSA and PSA, with a weak but not significant effect, are appropriate to be inert placebo controls in RCTs for chronic pain.
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Curr Pain Headache Rep · Jun 2020
Review Retracted PublicationGut Microbiome Dysbiosis and Depression: a Comprehensive Review.
The human gut microbiome is involved in a bi-directional communication pathway with the central nervous system (CNS), termed the microbiota-gut-brain axis. The microbiota-gut-brain axis is believed to mediate or modulate various central processes through the vagus nerve. The microbiota-gut-brain axis is involved with the production of microbial metabolites and immune mediators which trigger changes in neurotransmission, neuroinflammation, and behavior. Little is understood about the utilization of microbiome manipulation to treat disease. ⋯ Though studies exploring the role of the microbiome in various disease processes have shown promise, mechanisms remain unclear and evidence-based treatments for most illnesses have not yet been developed. The animal studies reviewed in the present investigation include an array of basic science studies that clarify mechanisms by which the microbiome may affect mental health. More evidence is needed, particularly as it relates to translating this work to humans. The studies presented in this review demonstrate encouraging results in the treatment of depression. Limitations include small sample sizes and heterogeneous methodology. The exact mechanism by which the gut microbiota causes or alters neuropsychiatric disease states is not fully understood. In this review, we focus on recent studies investigating the relationship between gut microbiome dysbiosis and the pathogenesis of depression.