Articles: hyoscine-therapeutic-use.
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Randomized Controlled Trial Clinical Trial
[Transdermal scopolamine for prevention of postoperative nausea and vomiting. No clinically relevant result in spite of reduced postoperative vomiting in general surgical and gynecologic patients].
In a prospective double-blind trial, transdermal scopolamine (TS) was compared to placebo (P) in the prevention of postoperative nausea and vomiting (PONV) within a 48-h interval. After stratification for gender and surgical procedure, patients were randomly chosen to receive either TS or placebo. ⋯ The routine administration of TS for gynaecological and surgical patients cannot be recommended because of the lack of effect on postoperative nausea and only marginal benefit concerning postoperative vomiting.
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Aviat Space Envir Md · Mar 1996
Clinical Trial Controlled Clinical TrialThe efficacy of hyoscine hydrobromide in reducing side-effects induced during immersion in virtual reality.
Regan and Price (1994) investigated the frequency of occurrence and severity of side-effects of using an immersion virtual reality system in 150 subjects: 61% of the subjects reported symptoms of malaise at some point during a 20-min immersion and 10-min post-immersion period. This paper describes a double-blind placebo-controlled study that investigated whether 300 microgram of hyoscine/scopolamine hydrobromide administered to subjects prior to immersion in virtual reality was effective in reducing side-effects experienced during immersion. ⋯ The results of the study showed that the hyoscine was effective in reducing symptoms that are commonly observed during immersion in virtual reality.
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Randomized Controlled Trial Clinical Trial
Scopolamine patch reduces postoperative emesis in paediatric patients following strabismus surgery.
Scopolamine patch was evaluated for the prevention of postoperative emesis in 50 children undergoing strabismus surgery. All subjects were premedicated, with none receiving narcotic premedicants. ⋯ Before operation, the subjects were randomly assigned to one of two groups: a treatment group received a scopolamine patch at a dose of either 0.75 mg or 0.375 mg, and a control group received no patch. Both the incidence and frequency of vomiting in the scopolamine-treated group were significantly (P less than 0.05) lower than in the control group.
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Anaesthesiol Reanim · Jan 1991
Review Comparative Study Clinical Trial Controlled Clinical TrialCardiac dysrhythmias during dental surgery. Comparison of hyoscine, glycopyrrolate and placebo premedication.
The incidence of cardiac dysrhythmias was investigated in 60 patients undergoing dental operations under halothane anaesthesia following either hyoscine, glycopyrrolate or placebo as a supplement to nalbuphine for premedication. Forty-five percent of the patients given 6 micrograms/kg hyoscine exhibited cardiac dysrhythmias compared to 25 percent of the group given 4 micrograms/kg glycopyrrolate and to 5 percent in the placebo group. ⋯ There was neither a connection between the frequency of cardiac dysrhythmias and the demographic characteristics of the patients nor with their PaCO2. The author recommends to avoid premedication with anticholinergic combined with halothane anaesthesia with spontaneous respiration during dental operations.
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Biography Historical Article
Key witness against morning sickness drug faces scientific fraud charges.