Articles: propofol.
-
Randomized Controlled Trial Comparative Study Clinical Trial
Recovery after day-case anaesthesia. A 24-hour comparison of recovery after thiopentone or propofol anaesthesia.
Sixty patients who presented for day-case dilatation and curettage were allocated randomly to receive either thiopentone or propofol for induction and maintenance of anaesthesia. One anaesthetist administered all the anaesthetics whilst all assessments were made by one other. ⋯ There was a significant difference in subjective feelings of tiredness and drowsiness recorded by the two study groups at 24 hours. Memory function assessed by Wechsler logical memory function passages at 24 hours was impaired in the propofol group in comparison to a group of 'reference' subjects.
-
Anesthesia and analgesia · Nov 1990
Randomized Controlled Trial Clinical TrialIs the antiemetic effect of the emulsion formulation of propofol due to the lipid emulsion?
The hypothesis that the lipid emulsion of the emulsion formulation of propofol is responsible for the low frequency of nausea, retching, and vomiting after propofol anesthesia was tested. A randomized, prospective, and comparative study was performed to evaluate the antiemetic effect of 10% lipid solution in 60 women, ASA physical status I and II, scheduled for ambulatory laparoscopic procedures. Two groups of patients were studied. ⋯ The groups were similar with respect to duration of anesthesia, characteristics of early and intermediate recovery, as well as pain scores in the postanesthesia care unit. There were no differences in the amount of antiemetic medications administered or postoperative nausea, retching, or vomiting when the patients were evaluated objectively by a blinded observer or subjectively by patient self-evaluation. It is concluded that 10% Intralipid, the lipid in the emulsion formulation of propofol, does not possess significant antiemetic effects.
-
The results of a trial with Propofol for conscious sedation in mentally and/or physically handicapped and extremely anxious dental patients is presented. A continuous intravenous infusion of Propofol was chosen as a method of administration with slow and careful titration until the appropriate level of sedation was reached. ⋯ The depth of sedation is easily and rapidly controlled by the rate of the infusion. The recovery was rapid, the patients were clear headed and devoid of any early and late postoperative sequelae.