Articles: sepsis.
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Randomized Controlled Trial Clinical Trial
The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis [ISRCTN28863830].
In this prospective, randomized controlled study, we aimed to evaluate the effect of IgM-enriched immunoglobulin treatment on progression of organ failure and septic shock in patients with severe sepsis. ⋯ Present data could not demonstrate any beneficial effects of polyclonal immunoglobulin preparation Pentaglobin on organ morbidity, septic shock incidence and mortality rate in patients with severe sepsis.
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Randomized Controlled Trial Clinical Trial
In vivo effect of rhGM-CSF And rhG-CSF on monocyte HLA-DR expression of septic neonates.
To investigate the effect of rhGM-CSF and rhG-CSF on the monocyte HLA-DR expression of septic neonates. ⋯ The monocyte HLA-DR expression is depressed on the onset of neonatal sepsis and is progressively restored during the following days. Treatment with rhGM-CSF results in an earlier increase of the number of monocytes expressing the HLA-DR.
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Randomized Controlled Trial Clinical Trial
Physiological-dose steroid therapy in sepsis [ISRCTN36253388].
The aim of the study was to assess the prognostic importance of basal cortisol concentrations and cortisol response to corticotropin, and to determine the effects of physiological dose steroid therapy on mortality in patients with sepsis. ⋯ There was a trend towards a decrease in the mortality rates of the patients with sepsis who received physiological-dose steroid therapy. In the advancing process from sepsis to septic shock, adrenal insufficiency was not frequent as supposed. There was a trend (that did not reach significance) towards a decrease in the mortality rates of the patients with sepsis who received physiological-dose steroid therapy.
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Randomized Controlled Trial Clinical Trial
Early nasojejunal feeding in acute pancreatitis is associated with a lower complication rate.
We investigated the effect of early jejunal feeding on septic complications and mortality rate in patients with acute pancreatitis in a two-phase, prospective, controlled study. ⋯ We believe that the combination of early enteral nutrition and selective, adequate antibiotic prophylaxis may prevent multiple organ failure in patients with acute pancreatitis.
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Intensive care medicine · Mar 2002
Randomized Controlled Trial Multicenter Study Clinical TrialDobutamine and gastric-to-arterial carbon dioxide gap in severe sepsis without shock.
To evaluate the effect of an early dobutamine infusion on gastrointestinal perfusion in patients with severe sepsis. ⋯ An early infusion of dobutamine at a fixed dose of 5 microg/kg per min during the first 72 h of severe sepsis does not influence gastric DeltaCO2.