Articles: sepsis.
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Clin J Am Soc Nephrol · May 2007
Multicenter StudySeptic acute kidney injury in critically ill patients: clinical characteristics and outcomes.
Sepsis is the most common cause of acute kidney injury (AKI) in critical illness, but there is limited information on septic AKI. A prospective, observational study of critically ill patients with septic and nonseptic AKI was performed from September 2000 to December 2001 at 54 hospitals in 23 countries. A total of 1753 patients were enrolled. ⋯ There was a trend to lower serum creatinine (106 [73 to 158] versus 121 [88 to 184] mumol/L; P = 0.01) and RRT dependence (9 versus 14%; P = 0.052) at hospital discharge for septic AKI. Patients with septic AKI were sicker and had a higher burden of illness and greater abnormalities in acute physiology. Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT.
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Revista médica de Chile · May 2007
Multicenter Study[Prevalence of severe sepsis in intensive care units. A national multicentric study].
Severe sepsis (SS) is the leading cause of death in the Intensive Care Units (ICU). ⋯ SS is highly prevalent in Chilean ICUs and represents the leading diagnosis at admission. SS as cause of hospitalization, APACHE II and SOFA scores were independent predictors of mortality.
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Patients with chronic kidney disease are at high risk for sepsis and sepsis-related mortality. ⋯ Use of statins was strongly and independently associated with a reduction in the risk of sepsis events [corrected] in patients who had chronic kidney disease and were receiving dialysis. Randomized trials of statins in patients with chronic kidney disease should examine the prevention of sepsis as a potentially important benefit.
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Intensive care medicine · Apr 2007
Randomized Controlled Trial Multicenter StudyEpidemiology of sepsis in Germany: results from a national prospective multicenter study.
To determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size. ⋯ The expected number of newly diagnosed cases with severe sepsis in Germany amounts to 76-110 per 100,000 adult inhabitants. To allow better comparison between countries, future epidemiological studies should use standardized study methodologies with respect to sepsis definitions, hospital size, and daily and monthly variability.