Articles: sepsis.
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Minerva anestesiologica · Nov 2024
Meta AnalysisDiagnostic value of circulating IL-6 in adult sepsis: a meta-analysis.
In recent years, numerous studies have been published on the diagnostic performance of circulating IL-6 levels in adult sepsis, but the conclusions are not consistent. This meta-analysis aims to systematically evaluate the accuracy of circulating IL-6 in the diagnosis of adult sepsis. ⋯ Circulating IL-6 has a good diagnostic value in adult sepsis, with moderate sensitivity and specificity. Therefore, IL-6 can provide a basis for the diagnosis of adult sepsis.
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Critical care medicine · Nov 2024
Randomized Controlled TrialModulation of Metabolomic Profile in Sepsis According to the State of Immune Activation.
To investigate the metabolomic profiles associated with different immune activation states in sepsis patients. ⋯ Findings suggest distinct metabolic dysregulation patterns associated with different immune dysfunctions in sepsis: the strongest metabolic dysregulation is associated with MALS.
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Intensive care medicine · Nov 2024
ReviewComplement system activation: bridging physiology, pathophysiology, and therapy.
The complement system is a set of over 50 proteins that constitutes an essential part of the innate immune system. Complement system activation involves an organized proteolytic cascade. Overactivation of complement system activation is the main pathogenic mechanism of several diseases and contributes to the manifestations of many other conditions. ⋯ The complement system is crucial to health but, when overactivated, can cause or contribute to disease. Effective complement inhibitors are now available, although additional data are required to determine optimal regimens. Further research is also needed to better understand the complement system, develop advanced diagnostic tools, and identify markers that allow the personalization of treatment strategies.
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Acta Anaesthesiol Scand · Nov 2024
Comparative StudyComorbid burden at ICU admission in COVID-19 compared to sepsis and acute respiratory distress syndrome.
Comorbidities are similarly associated with short-term mortality for COVID-19, acute respiratory distress syndrome (ARDS) and sepsis in intensive care unit (ICU) patients, but their adjusted frequencies at admission are unknown. Thus, we aimed to evaluate the adjusted distribution, reported as odds ratios, of known risk factors (i.e., age, sex and comorbidities) for ICU admission between COVID-19, sepsis and ARDS patients in this nationwide registry-based study. ⋯ Patients admitted to ICU with sepsis or ARDS carry a heavier burden of comorbidity and high age than patients admitted with COVID-19. This is likely caused by a combination of: (1) respiratory failure in COVID-19 being less dependent on comorbidities than in other forms of ARDS, and the cause of critical illness in other infections causing sepsis and (2) COVID-19 patients being deferred admission in situations where patients with the other syndromes were admitted.
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Pediatr Crit Care Me · Nov 2024
Multicenter Study Observational StudyDiagnostic Validation of the Updated Pediatric Sepsis Biomarker Risk II for Acute Kidney Injury Prediction Model in Pediatric Septic Shock.
We previously derived the updated Pediatric Sepsis Biomarker Risk for Acute Kidney Injury (PERSEVERE-II AKI) prediction model, which had robust diagnostic test characteristics for severe AKI on day 3 (D3 severe AKI) of septic shock. We now sought to validate this model in an independent cohort of children to the one in which the model was developed. ⋯ The PERSEVERE-II AKI model demonstrates consistently robust performance for prediction of new or persistent D3 severe AKI in children with septic shock. A major limitation is that actual D3 severe AKI prevalence is below the prevalence threshold for the test, and thus future work should focus on evaluating use in enriched populations.