Articles: sepsis.
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Journal of critical care · Feb 2020
Randomized Controlled Trial Multicenter StudyGender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study.
To assess the impact of gender and pre-menopausal state on short- and long-term outcomes in patients with septic shock. ⋯ This post-hoc analysis of a large multi-center trial in early septic shock has shown no short- or long-term survival effect for women overall as well as in the pre-menopausal age-group.
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Multicenter Study
Sepsis and septic shock in emergency departments of Mexico: a multicenter point prevalence study.
Sepsis is one of the main reasons for consultation at emergency departments. ⋯ Se encontró alta prevalencia de la sepsis en los servicios de urgencias médicas mexicanos. La mortalidad de los pacientes con choque séptico fue similar e, incluso, mayor a la reportada internacionalmente.
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Randomized Controlled Trial Multicenter Study Comparative Study
Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial.
In the context of optimal, individualised lung ventilation, high inspired oxygen does not reduce surgical infections compared with conventional FiO2.
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Critical care medicine · Jan 2020
Multicenter Study Observational StudyBioactive Adrenomedullin, Organ Support Therapies, and Survival in the Critically Ill: Results from the French and European Outcome Registry in ICU Study.
Adrenomedullin has vascular properties and elevated plasma adrenomedullin levels were detected in sepsis. We assessed, in septic and nonseptic ICU patients, the relation between circulating adrenomedullin, the need for organ support and mortality, using an assay of bioactive adrenomedullin. ⋯ Early measurement of bioactive adrenomedullin is a strong predictor of the need of organ support and of short-term mortality in critically ill patients.
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Multicenter Study Observational Study
Early diagnosis of sepsis in emergency departments, time to treatment, and association with mortality: An observational study.
Early recognition of sepsis is critical for timely initiation of treatment. The first objective of this study was to assess the timeliness of diagnostic procedures for recognizing sepsis in emergency departments. We define diagnostic procedures as tests used to help diagnose the condition of patients. The second objective was to estimate associations between diagnostic procedures and time to antibiotic treatment, and to estimate associations between time to antibiotic treatment and mortality. ⋯ Key procedures for recognizing sepsis were delayed or not completed in a substantial proportion of patients admitted to the emergency department with sepsis. Delay or non-completion of key diagnostic procedures was associated with prolonged time to treatment with antibiotics. This suggests a need for systematic improvement in the initial management of patients admitted to emergency departments with sepsis.