Articles: sepsis.
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Critical care medicine · Aug 2015
Randomized Controlled TrialAn Electronic Tool for the Evaluation and Treatment of Sepsis in the ICU: A Randomized Controlled Trial.
To determine whether addition of an electronic sepsis evaluation and management tool to electronic sepsis alerting improves compliance with treatment guidelines and clinical outcomes in septic ICU patients. ⋯ A comprehensive electronic sepsis evaluation and management tool is feasible and safe but did not influence guideline compliance or clinical outcomes, perhaps due to low utilization.
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Randomized Controlled Trial
Improved sepsis bundles in the treatment of septic shock: a prospective clinical study.
Sepsis bundles can decrease mortality in patients with severe sepsis or septic shock. However, current methods of measuring pressure, such as central venous pressure, are inadequate. This study investigated the effect of improved sepsis bundles informed by pulse-indicated continuous cardiac output. ⋯ Pulse-indicated continuous cardiac output-directed sepsis bundles can reduce the severity of septic shock, provide more accurate fluid resuscitation, and reduce the duration of mechanical ventilation and stay in the intensive care unit.
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Critical care medicine · Jul 2015
Randomized Controlled TrialDrug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis.
The recent withdrawal of a targeted sepsis therapy has diminished pharmaceutical enthusiasm for developing novel drugs for the treatment of sepsis. Angiopoietin-2 is an endothelial-derived protein that potentiates vascular inflammation and leakage and may be involved in sepsis pathogenesis. We screened approved compounds for putative inhibitors of angiopoietin-2 production and investigated underlying molecular mechanisms. ⋯ 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors may operate through a novel Foxo1-angiopoietin-2 mechanism to suppress de novo production of angiopoietin-2 and thereby ameliorate manifestations of sepsis. Given angiopoietin-2's dual role as a biomarker and candidate disease mediator, early serum angiopoietin-2 measurement may serve as a stratification tool for future trials of drugs targeting vascular leakage.
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Zhongguo Zhong Xi Yi Jie He Za Zhi · Jul 2015
Randomized Controlled Trial[Effect of Acupuncture on Prognosis and Immune Function of Sepsis Patients].
To study the effect of acupuncture on the immune function of sepsis patients. ⋯ Acupuncture could adjust the immune function of sepsis patients, improve their immunological indicators and prognoses.
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Randomized Controlled Trial
Ubiquinol (reduced coenzyme Q10) in patients with severe sepsis or septic shock - a randomized, double-blind, placebo-controlled, pilot trial.
We previously found decreased levels of Coenzyme Q10 (CoQ10) in patients with septic shock. The objective of the current study was to assess whether the provision of exogenous ubiquinol (the reduced form of CoQ10) could increase plasma CoQ10 levels and improve mitochondrial function. ⋯ In this pilot trial we showed that plasma CoQ10 levels could be increased in patients with severe sepsis or septic shock, with the administration of oral ubiquinol. Further research is needed to address whether ubiquinol administration can result in improved clinical outcomes in this patient population.