Articles: chronic.
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COPD Rehabilitation PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: In elderly patients the association between chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD) is common and predisposes to severe complications and marked restrictions of daily activity. The aim was to evaluate the results of exercise training of the rehabilitation programs in patients with mild or moderate COPD and stable chronic ischemic heart disease (CIHD). ⋯ The following authors have nothing to disclose: Corina Cozma Dima, Clementina Doina Cojocaru, Paraschiva PostolacheNo Product/Research Disclosure Information.
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Critical Care Case Report PostersSESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: Diffuse alveolar hemorrhage (DAH) is associated with negative pressure pulmonary edema secondary to acute upper airway obstruction. There have been no associations with the upper airway obstruction of obstructive sleep apnea. Negative intrathoracic pressure leads to an increase in pulmonary vascular volume and pulmonary capillary transmural pressure, creating a risk of disruption of the alveolar-capillary membrane. We present a case of DAH in a patient on anticoagulation with positive anti-cardiolipin antibody and low level anti-dsDNA triggered by severe obstructive sleep apnea. ⋯ The following authors have nothing to disclose: Sadaf Mir, Silviana Marineci, Mary O'SullivanNo Product/Research Disclosure Information.
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COPD Comorbidity PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: To evaluate the characteristics and occurrence of anxiety and depression among older patients hospitalized for acute exacerbation of COPD (AECOPD) in a multi ethnicity population. ⋯ The following authors have nothing to disclose: Sana' AL Aqqad, Irfhan Ali Hyder Ali, Razul Md. Nazri Md. Kassim, Azmi Sarriff, Balamurugan TangiisuranNo Product/Research Disclosure Information.
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The incidence of death among patients admitted for severe sepsis or septic shock is high. Adrenomedullin (ADM) plays a central role in initiating the hyperdynamic response during the early stages of sepsis. Pilot studies indicate an association of plasma ADM with the severity of the disease. In the present study we utilized a novel sandwich immunoassay of bioactive plasma ADM in patients hospitalized with sepsis in order to assess the clinical utility. ⋯ In patients admitted with sepsis, severe sepsis or septic shock plasma ADM is strongly associated with severity of disease, vasopressor requirement and 28-day mortality.
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Am. J. Respir. Crit. Care Med. · Feb 2014
Deficiency of MDA5 Results in Exacerbated Chronic Post-Viral Lung Inflammation.
Respiratory viral infections can result in the establishment of chronic lung diseases. Understanding the early innate immune mechanisms that participate in the development of chronic postviral lung disease may reveal new targets for therapeutic intervention. The intracellular viral sensor protein melanoma differentiation-associated protein 5 (MDA5) sustains the acute immune response to Sendai virus, a mouse pathogen that causes chronic lung inflammation, but its role in the development of postviral chronic lung disease is unknown. ⋯ MDA5 modulates the development of chronic lung inflammation by regulating the early inflammatory response in the lung.