Articles: chronic.
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Infectious Disease Case Reports Posters IIISESSION TYPE: Case Report PosterPRESENTED ON: Sunday, March 23, 2014 at 01:15 PM - 02:15 PMINTRODUCTION: The most common cause of granulomatous inflammation of lung in India is tuberculosis (TB), other etiologies need to be considered if the clinical scenario is not consistent with TB. We present an unusual cause of granuloma, which remained elusive for over two and half years. ⋯ Chronic aspergillosis presenting as lung and kidney mass in apparently immunocompetent host has been rarely reported. Fungal infections need to be considered as a cause of granulomatous inflammation even in tuberculosis endemic countries.Reference #1: Kang EY, Kim DH etal. Pulmonary aspergillosis in immunocompetent hosts without underlying lesions of the lung: radiologic and pathologic findings.Am J Roentgenol. 2002 Jun;178(6):1395-9.Reference #2: Yoon SH, Park CM et al. Pulmonary aspergillosis in immunocompetent patients without air-meniscus sign and underlying lung disease: CT findings and histopathologic features. Acta Radiol. 2011 Sep 1;52(7):756-61.Reference #3: Myerson DA, Rosenfield AT. Renal aspergillosis: a report of two cases.J Can Assoc Radiol. 1977 Sep;28(3):214-6DISCLOSURE: The following authors have nothing to disclose: Vishwanath Gella, Srinivas Upendra, Adarsh BarwadNo Product/Research Disclosure Information.
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Slide PresentationsPRESENTED ON: Sunday, March 23, 2014 at 04:15 PM - 05:15 PMPURPOSE: The purpose of this study was to evaluated the effect of triple-combined long acting inhaled bronchodilator treatment with roflumilast and dual-combined long acting inhaled bronchodilator and single-long acting inhaled bronchodilator treatment on exacerbations in patients with severe and very severe chronic obstructive pulmonary disease(COPD). ⋯ The following authors have nothing to disclose: Alizamin Sadigov, Sakhavatdin Akhundov, Rovshan BagirovNo Product/Research Disclosure Information.
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Bronchiectasis PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Evaluate the characteristics of patients with chronic obstructive pulmonary disease (COPD) and bronchiectasis. ⋯ The following authors have nothing to disclose: Maria João Oliveira, Daniel Coutinho, Daniel Vaz, Maria do Céu BritoNo Product/Research Disclosure Information.
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The incidence of death among patients admitted for severe sepsis or septic shock is high. Adrenomedullin (ADM) plays a central role in initiating the hyperdynamic response during the early stages of sepsis. Pilot studies indicate an association of plasma ADM with the severity of the disease. In the present study we utilized a novel sandwich immunoassay of bioactive plasma ADM in patients hospitalized with sepsis in order to assess the clinical utility. ⋯ In patients admitted with sepsis, severe sepsis or septic shock plasma ADM is strongly associated with severity of disease, vasopressor requirement and 28-day mortality.
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Am. J. Respir. Crit. Care Med. · Feb 2014
Deficiency of MDA5 Results in Exacerbated Chronic Post-Viral Lung Inflammation.
Respiratory viral infections can result in the establishment of chronic lung diseases. Understanding the early innate immune mechanisms that participate in the development of chronic postviral lung disease may reveal new targets for therapeutic intervention. The intracellular viral sensor protein melanoma differentiation-associated protein 5 (MDA5) sustains the acute immune response to Sendai virus, a mouse pathogen that causes chronic lung inflammation, but its role in the development of postviral chronic lung disease is unknown. ⋯ MDA5 modulates the development of chronic lung inflammation by regulating the early inflammatory response in the lung.