Articles: function.
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Arch Phys Med Rehabil · Nov 2013
Comparative StudyWalking ability and quality of life in subjects with transfemoral amputation: a comparison of osseointegration with socket prostheses.
To investigate walking ability and quality of life of osseointegrated leg prostheses compared with socket prostheses. ⋯ Osseointegration is a suitable intervention for persons whose prosthesis use is reduced because of socket-related problems. Subjects with OIP significantly increased their walking ability and prosthesis-related quality of life.
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Comparative Study Clinical Trial
Two-Year Follow-up in Patients Treated With Emphysematous Lung Sealant for Advanced Emphysema.
Endoscopic lung volume-reduction therapy for emphysema has been associated with therapeutic responses smaller in magnitude and less durable than surgical volume reduction (LVRS). Bronchoscopic emphysematous lung sealant (ELS) therapy has been shown to produce improvements in pulmonary function similar to surgery at 1 year. This case series summarizes safety and efficacy data of all patients from the initial ELS study out to 2 years. ⋯ An exponential model fit to FEV₁ data at 6, 12, 18, and 24 months predicted improvements from a baseline of > 5% out to 4.1 years, similar to what has been reported following surgery. This report confirms long-term safety and efficacy following ELS therapy in advanced emphysema. Studies in a larger cohort are needed to define the role of ELS therapy in the treatment algorithm of patients with this condition.
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Clinical lung cancer · Nov 2013
Interdisciplinary palliative care intervention in metastatic non-small-cell lung cancer.
Challenges and barriers continue to hinder the integration of palliative care models into comprehensive, ambulatory oncology care. This article aims to describe how symptoms, distress, and quality of life (QOL) data from the usual care phase of a National Cancer Institute-supported Program Project informed the development of an interdisciplinary, tailored palliative care intervention for patients with metastatic non-small-cell lung cancer (NSCLC). ⋯ Patients with metastatic NSCLC continue to experience high symptom burden and diminished physical well-being over time while receiving cancer treatments. An interdisciplinary palliative care intervention is currently being tested to improve symptom burden and overall QOL.
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Obesity confers a survival advantage in the critically ill and in patients undergoing cardiac surgery. We explored whether an obesogenic high fat diet could confer protection against post cardiopulmonary bypass (CPB) acute kidney injury (AKI) in a swine model. ⋯ A high fat diet promoted obesity and renal inflammation and prevented post CPB AKI in swine. This study provides insights into the obesity paradox and the failure of anti-inflammatory interventions to improve clinical outcomes in patients at risk of post cardiac surgery AKI.
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Modulation of L-type Ca(2+)-channel function by dopamine is a major determinant of the rate of action potential firing by striatal medium spiny neurons (MSNs). However, the role of these channels in modulating GABA release by nerve terminals in the basal ganglia is unknown. We found that depolarization induced [(3)H]GABA release in both the substantia nigra reticulata and the external globus pallidus, was depressed by about 50% by either the selective L-channel dihydropiridine blocker nifedipine or the P/Q channel blocker ω-agatoxin TK. ⋯ In the globus pallidus nifedipine blocked the effects of D2 and A2A receptor coactivation as well as the effects of activating adenylyl cyclase with forskolin. ω-agatoxin TK did not interfere with the action of these modulatory agents. The L-type Ca(2+)-channel agonist BAYK 8644 stimulated GABA release in both substantia nigra reticulata and globus pallidus. Because dihydropiridine sensitivity is a key criteria to identify L-type Ca(2+)-channel activity, our results imply that these channels are determinant of GABA release modulation by dopamine in striatonigral, striatopallidal and pallidonigral terminals.