Articles: function.
-
Meta Analysis
Effects of cilostazol on cognitive function and dementia risk: A systematic review and meta-analysis.
Cilostazol is an antiplatelet drug and is used for stroke prevention and symptomatic peripheral vascular disease. Studies have reported the effects of cilostazol on cognitive function, but the results are inconsistent and have not been systematically assessed. ⋯ These results suggest the potential for cilostazol treatment in the suppression of cognitive decline and prevention of progression to dementia. However, the lack of blinding in most studies is likely to cause an overestimation of the effect sizes, and further well-designed studies are also needed.
-
Preterm birth is a significant public health concern. To achieve a growth trajectory consistent with the genetic law, a catch-up growth strategy must be adopted for these infants to achieve normal growth and development. The aim of this study is to investigate the use requirements of a WeChat mini program-based post-discharge catch-up growth follow-up management system for the parents of preterm infants. ⋯ The factors that influence the demand for WeChat mini program functions for managing the catch-up growth of preterm infants after discharge include occupation, education level, family structure, number of births, residential area, and frequency of using WeChat (P < .05). The demand for the WeChat mini program for post-discharge catch-up growth management among parents of preterm babies is high. The contents and functions of the WeChat mini program can be further enriched and improved to meet the needs of parents of preterm infants of different birth ages.
-
Dilated cardiomyopathy (DCM) is characterized by ventricular dilation and poor systolic function. Approximately half of idiopathic DCM cases are assigned to genetic causes in familial or apparently sporadic cases, and more than 50 genes are reported to cause DCM. However, genetic basis of most DCM patients still keeps unknown and require further study. ⋯ Bioinformatic analysis predicted p. G218R mutation as deleterious and pathogenic damaging in DCM patients. Our results reported a potential pathogenic mutation associated with DCM, which may provide further insight into genetic contributions of LAMA4 gene mutations to DCM phenotypes.
-
The study aimed to compare the morphometric and morphologic analyses of the bone structures of temporomandibular joint and masticatory muscles on Cone beam computed tomography (CBCT) in 62 healthy subjects and 33 subjects with temporomandibular dysfunction (TMDS) aged between 18 and 56 years. In addition, a machine learning (ML) pipeline involving the Random Forest classifier was used to automatically detect TMDS. Thirty parameters (including age and gender) associated with the condylar process, articular tubercle, mandibular fossa, ramus mandible, joint space, and masticatory muscles were examined using CBCT. ⋯ The reference values of the condylar process, articular tubercle, mandibular fossa, ramus of mandible, and joint space may play a key role in increasing of the success of the surgical procedure, or the assessment/differentiating of the TMD. ML is capable of detecting TMD in an automatic and highly accurate way. Hence, it is also concluded that ML can be useful for cases requiring making automatic and highly correct predictions.