Articles: function.
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Southern medical journal · Jan 2023
Impact of Pulmonary Hypertension on Renal Functions in Obstructive Sleep Apnea Syndrome.
Pulmonary hypertension (PH) is common in obstructive sleep apnea syndrome (OSAS). This study aimed to evaluate the effect of PH on kidney functions in patients with OSAS. ⋯ PH is a risk factor for the deterioration of renal function in OSAS and more prominent in the long term.
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Microvascular free‑flap monitoring is crucial to the early detection of flap failure and increases the chance of early intervention in case of disruption of perfusion to a flap. Many clinical alternatives to classical clinical flap monitoring have been proposed, such as color duplex ultrasonography, handheld Doppler, flap thermometry, or implantable Doppler flowmetry. Early detection of critical changes in tissue oxygenation can lead to successful surgical intervention when problems with flap nutrition arise. ⋯ In our study, the continuous NIRS monitoring securely detected the early stages of arterial and venous thromboses or pedicle compression. The most important aspects of monitoring the flaps´ microvascular perfusion and vitality by means of NIRS lie in its function of recording the dynamics of changes in the values of absolute oxygen saturation (StO2> 50%) alongside with detecting a 30% decrease in tissue saturation over a 60‑minute interval (60 min StO2 >30%) before the clinical changes in the microvascular flap become observable. In cases of pedicle compression, the average time of appearance of signs of StO2 values dropping below the reference interval (as detected by NIRS) was 1:29:02 hour (SD= 0:58:42 h) prior to the occurrence of any clinical signs, while in cases of microvascular anastomosis complications, it was 0:35:23 hour (SD=0:08:30 h) (SD = 0:08:30 h) (Tab. 3, Fig. 7, Ref. 42).
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The cell cycle covers cell proliferation and growth and is strictly regulated by cyclin-dependent kinase, cyclins and their inhibitors. Cyclin-dependent kinases are serine/threonine kinases that are activated in certain phases of the cell cycle by regulatory subunits, cyclins, with which they form functional heterodimeric complexes. Under physiological conditions, the activation of cyclin-dependent kinases and cyclins is strictly controlled. ⋯ Each cell cycle consists of two phases, interphase and mitotic phase. Their dysregulation leads to disruption of cell cycle coordination and uncontrollable cell proliferation, which is the main feature of tumorigenesis (Fig. 1, Ref. 69). Keywords: cell cycle, regulation, cyclin‑dependent kinases, cyclins, inhibitors.
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To investigate the effect and efficacy of traditional Chinese and western medicine combined with lung rehabilitation training on pulmonary function in patients with chronic obstructive pulmonary disease(COPD) complicated with chronic cor pulmonale. ⋯ Traditional Chinese and western medicine combined with lung rehabilitation training displayed better results on lung function and curative effect than conventional western medicine combined with lung rehabilitation training in patients with COPD complicated with chronic cor pulmonale (Tab. 8, Ref. 43). Text in PDF www.elis.sk Keywords: traditional Chinese and western medicine combined, lung rehabilitation training, chronic obstructive pulmonary disease, pulmonary function, curative effect.