Articles: function.
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Acta Anaesthesiol Scand · Jul 2016
CommentRocuronium pharmacokinetics and pharmacodynamics in the adductor pollicis and masseter muscles.
The aim of this study was to characterize the dose-effect relationship of rocuronium at the adductor pollicis and masseter muscles. ⋯ We found that the masseter muscle has faster onset of blockade and similar recovery profile than adductor pollicis muscle. These findings were best, explained by a faster plasma effect-site equilibration of the masseter muscle to rocuronium.
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Observational Study
The Heterogeneity Of Headache Patients Who Self-Medicate: A Cluster Analysis Approach.
Patients with headache often self-treat their condition with over-the-counter analgesics. However, overuse of analgesics can cause medication-overuse headache. The present study aimed to identify subgroups of individuals with headache who self-medicate, as this could be helpful to tailor intervention strategies for prevention of medication-overuse headache. ⋯ Cluster 3 (n = 222, 21.7%) mostly consisted of patients with migraine who also report pain in many other locations. These patients reported a high disability and a severe limitation of activities. They also showed the highest rates of MO (73%).