Articles: sars-cov-2.
-
Rocz Panstw Zakl Hig · Jan 2020
Covid-19: a survey on knowledge, awareness and hygiene practices among dental health professionals in an Indian scenario.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) continues to spread globally. It has become a major cause of concern for health care professionals all over the world. ⋯ The findings of the present study showed that some notable deficiencies in knowledge existed among dental professionals regarding some vital aspects of COVID-19. Therefore, there is an urgent need for improving dentists’knowledge via health education and training programs. Further studies on the subject are also warranted once the situation normalizes.
-
Clin. Appl. Thromb. Hemost. · Jan 2020
Evidence-Based Practical Guidance for the Antithrombotic Management in Patients With Coronavirus Disease (COVID-19) in 2020.
This practical guidance, endorsed by the Brazilian Society of Thrombosis and Hemostasis and The Brazilian Society of Angiology and Vascular Surgery, the International Union of Angiology and the European Venous Forum, aims to provide physicians with clear guidance, based on current best evidence-based data, on clinical strategies to manage antithrombotic strategies in patients with coronavirus disease 2019.
-
A total of 262 COVID-19-confirmed patients and 157 healthy controls were included in the study. ⋯ The mean vitamin D level in the COVID-19 group (12.8±8.9 ng/mL) was significantly lower than the control group (15.2±12.1 ng/mL) (p=0.015). The rate of those with vitamin D levels below 10 ng/mL in the COVID- 19 group (49.6%) was significantly higher than the control group (39.5%) (p=0.044). In the logistic regression analysis, it was found that those with a vitamin D level below 10 ng/mL had a 1.508-fold increased risk of COVID-19 compared to those who had 10 ng/mL and above (Odds ratio: 1.01-2.252). According to the risk analysis, those who have vitamin D levels below 20 ng/mL are 1,224 times higher than those who have 20 ng/mL and above; those under 30 ng/mL were found to have an increased risk of 2.01 times compared to those of 30 ng/mL and above. CONCLUSİONS: From the point of view of the literature data, we think that the findings we obtained may support researches that vitamin D level is significantly associated with both COVID-19 and other infections and many serious autoimmune and malignant diseases. As a result, rehabilitation programs on vitamin D deficiency should be organized and the society should be raised. KEY WORDS: Covid-19, Vitamin D25 (Oh) D.
-
Frontiers in immunology · Jan 2020
Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key?
To date the pathophysiology of COVID-19 remains unclear: this represents a factor determining the current lack of effective treatments. In this paper, we hypothesized a complex host response to SARS-CoV-2, with the Contact System (CS) playing a pivotal role in innate immune response. CS is linked with different proteolytic defense systems operating in human vasculature: the Kallikrein-Kinin (KKS), the Coagulation/Fibrinolysis and the Renin-Angiotensin (RAS) Systems. ⋯ Angiotensin-Converting-Enzyme (ACE) 2 displays lung protective effects: it inactivates DABK and converts Angiotensin II (Ang II) into Angiotensin-(1-7) and Angiotensin I into Angiotensin-(1-9). SARS-CoV-2 binds to ACE2 for cell entry, downregulating it: an impaired DABK inactivation could lead to an enhanced activity of B1-receptors, and the accumulation of Ang II, through a negative feedback loop, may result in decreased ACE activity, with consequent increase of BK. Therapies targeting the CS, the KKS and action of BK could be effective for the treatment of COVID-19.