Articles: prospective-studies.
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Anesthesia and analgesia · Aug 2017
Randomized Controlled TrialStroke Volume Variation-Guided Versus Central Venous Pressure-Guided Low Central Venous Pressure With Milrinone During Living Donor Hepatectomy: A Randomized Double-Blinded Clinical Trial.
We previously demonstrated the usefulness of milrinone for living donor hepatectomy. However, a less-invasive alternative to central venous catheterization and perioperative contributors to good surgical outcomes remain undetermined. The current study evaluated whether the stroke volume variation (SVV)-guided method can substitute central venous catheterization during milrinone-induced profound vasodilation. ⋯ Milrinone-induced vasodilation resulted in favorable surgical environment regardless of guidance methods of low CVP during living donor hepatectomy. However, SVV was not a useful indicator of low CVP because of very weak correlation between SVV and CVP during profound vasodilation. In addition, factors contributing to the best surgical field such as donor age, proactive fasting, and proper dosing of milrinone need to be investigated further, ideally through prospective studies.
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Randomized Controlled Trial Comparative Study
Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion after Adolescent Idiopathic Scoliosis: Prospective Randomized Double-blinded Study.
A prospective, randomized, double-blinded study. ⋯ 2.
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Randomized Controlled Trial
Impact of celecoxib on inflammation during cancer surgery: a randomized clinical trial.
During cancer surgery, prostaglandin-mediated inflammation may promote and activate micrometastatic disease with a consequent increase in long-term cancer recurrence. Cyclooxygenase-2 inhibitors, known to have anti-proliferative properties, may offset such perioperative perturbation. We investigated the effectiveness of these agents to minimize inflammatory changes during cancer surgery. ⋯ Standard dosing of the cyclooxygenase-2 inhibitor celecoxib slightly reduced perioperative cyclooxygenase activity during cancer surgery. Given cyclooxygenase's role in cancer pathways, we recommend dose-finding studies be undertaken before prospective clinical trials are conducted testing the currently unsubstantiated hypothesis that perioperative anti-inflammatory administration improves long-term cancer outcomes. This trial was registered at: Australian New Zealand Clinical Trial Registry: ACTRN12615000041550; www.anzctr.org.au.
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Randomized Controlled Trial Comparative Study
Intrathecal Versus Intravenous Morphine in Minimally Invasive Posterior Lumbar Fusion: A Blinded Randomized Comparative Prospective Study.
A blinded, randomized, comparative prospective study. ⋯ 2.
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Randomized Controlled Trial
An independent inter- and intra-observer agreement evaluation of the AOSpine subaxial cervical spine injury classification system.
An agreement study. ⋯ 3.