Articles: narcotic-antagonists.
-
Letter Randomized Controlled Trial Clinical Trial
Prophylactic epidural naloxone reduces the incidence and severity of neuraxial fentanyl-induced pruritus during labour analgesia in primiparous parturients.
-
Data on the cardiorespiratory changes and complications following administration of naloxone in children are limited. ⋯ Moderate increases in RR, HR, and BP occur after naloxone administration to children, but development of more serious complications is rare.
-
Drug Alcohol Depend · Oct 2003
Clinical Trial Controlled Clinical TrialPharmacokinetics of high-dose buprenorphine following single administration of sublingual tablet formulations in opioid naïve healthy male volunteers under a naltrexone block.
Sublingual buprenorphine formulations have been developed as treatments for opioid dependence. In three studies, opioid naïve healthy male subjects received Subutex tablets (buprenorphine 2 and 8 mg [N=27] or 12 and 16 mg [N=27]) or Suboxone (two formulations) tablets (buprenorphine 8 mg/naloxone 2 mg [N=36]) sublingually, under a naltrexone block for assessment of buprenorphine pharmacokinetics and tablet disintegration times. Plasma buprenorphine was quantified up to 72 h post-dose using a sensitive LC-MS/MS assay. ⋯ The least squares mean (90% CI) treatment ratio for Cmax was 1.00 (0.92-1.10) and AUC was 1.00 (0.95-1.06). Median times of disintegration were similar for all doses and formulations (range 6-12 min). Sublingual buprenorphine, up to 40 times the 400 microg analgesic dose, was well tolerated in these opioid naïve subjects, as administration of naltrexone 50-150 mg was sufficient to attenuate anticipated adverse effects in this population of subjects.
-
Randomized Controlled Trial Comparative Study Clinical Trial
Controlled trial of maintenance treatment of intravenous buprenorphine dependence.
Buprenorphine dependence is a relatively novel addiction. ⋯ These results support the efficacy and safety of oral methadone and sublingual buprenorphine tablets for injection buprenorphine-dependent patients.