Articles: spider-bites.
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Randomized Controlled Trial Multicenter Study
The Efficacy of Antivenin Latrodectus (Black Widow) Equine Immune F(ab')2 Versus Placebo in the Treatment of Latrodectism: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.
The antivenom currently available for treatment of systemic black widow envenomation (latrodectism) is composed of equine whole immunoglobin. Although considered effective, it has been associated with anaphylaxis and 2 reported fatalities. We test the efficacy and safety of new equine antivenom composed of purified F(ab')2 antibody fragments. ⋯ The F(ab')2 antivenom met the predefined primary outcome of reduced treatment failures. Secondary outcomes of pain intensity difference and summed pain intensity difference also supported efficacy. The rate of symptom improvement in the placebo group was higher than expected, which may be related to enrollment criteria or placebo effect.
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Randomized Controlled Trial Multicenter Study Comparative Study
Randomized Controlled Trial of Intravenous Antivenom Versus Placebo for Latrodectism: The Second Redback Antivenom Evaluation (RAVE-II) Study.
Latrodectism is the most important spider envenomation syndrome worldwide. There remains considerable controversy over antivenom treatment. We aimed to investigate whether antivenom resulted in resolution of pain and systemic effects in patients with latrodectism who received standardized analgesia. ⋯ The addition of antivenom to standardized analgesia in patients with latrodectism did not significantly improve pain or systemic effects.
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Br J Clin Pharmacol · Jan 2008
Randomized Controlled Trial Multicenter Study Comparative StudyA comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom.
There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV). ⋯ RBS AV given by the intramuscular route is unlikely to be effective in the treatment of redback (widow) spider bite.
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Emerg Med Australas · Apr 2005
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialA double-blind, randomized trial of intravenous versus intramuscular antivenom for red-back spider envenoming.
To compare the efficacy of intravenous versus intramuscular antivenom (AV) in the treatment of Red-back spider (RBS) envenoming. ⋯ Red-back spider antivenom was initially effective by both i.m. and i.v. routes. The study generates the hypothesis that at 24 h, significantly more patients are pain-free with i.v. administration. Definitive recommendations on the optimal route of administration of RBS AV await the results of further studies.