Articles: opioid.
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J Anaesthesiol Clin Pharmacol · Jul 2013
Effect of gender on pain perception and analgesic consumption in laparoscopic cholecystectomy: An observational study.
Evidence regarding gender affecting the response to pain and its treatment is inconsistent in literature. The objective of this prospective, observational study was to determine the effect of gender on pain perception and postoperative analgesic consumption in patients undergoing laparoscopic cholecystectomy. ⋯ Female patients exhibited greater intensity of pain and required higher doses of analgesics compared to males in in the immediate postoperative period in order to achieve a similar degree of analgesia.
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J Pain Symptom Manage · Jul 2013
Use of opioid analgesics among older persons with colorectal cancer in two health districts with palliative care programs.
Prescription of opioid analgesics is a key component of pain management among persons with cancer at the end of life. ⋯ PCPs may play an important role in enabling access to end-of-life care within the community.
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Nephrol. Dial. Transplant. · Jul 2013
Humoral signalling compounds in remote ischaemic preconditioning of the kidney, a role for the opioid receptor.
Renal ischaemia-reperfusion injury (IRI) is a common clinical problem associated with significant mortality and morbidity. One strategy to reduce this damage is remote ischaemic preconditioning (RIPC), in which brief ischaemia of a limb protects the kidney against a prolonged ischaemic insult. The mechanism of renal RIPC has not yet been elucidated. Here, we address the gap in our understanding of renal RIPC signalling, using a rat model of renal IRI and RIPC by brief hind limb ischaemia. ⋯ Renal RIPC by brief hind limb ischaemia may be the result of endorphin release from the hind limb. The importance of opioid signalling in renal RIPC provides vital clues for its successful translation to the clinical setting.
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The factors associated with successful opioid discontinuation after cancer treatment are not well-known. We determined the proportion of patients with advanced head and neck cancer who continued using opioids 3 months after the completion of radiation therapy with or without chemotherapy. ⋯ CAGE positivity is a risk factor for opioid use beyond 3 months after the completion of radiation therapy and for duration of opioid treatment. Routine CAGE screening and meticulous follow-up are needed for these patients.