Articles: acetaminophen.
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Randomized Controlled Trial Clinical Trial
Paracetamol as a prophylactic analgesic for hysterosalpingography: a double blind randomized controlled trial.
To evaluate the effectiveness of paracetamol as a prophylactic analgesic for hysterosalpingography (HSG). ⋯ Paracetamol is not effective as a prophylactic analgesic for HSG. If a prophylactic analgesic is considered necessary for pain relief during HSG we recommend that a non-steroidal anti-inflammatory drug (NSAID) is used.
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J Assoc Physicians India · Sep 2000
Comment Letter Case ReportsParacetamol (acetaminophen) poisoning: report of two cases.
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Paracetamol has mild analgesic and antipyretic properties and is, along with acetylsalicylic acid, one of the most popular "over the counter" analgesic agents. However, the mechanism underlying its clinical effects is unknown. Another drug whose mechanism of action is unknown is caffeine, which is often used in combination with other analgesics, augmenting their effect. ⋯ Whereas paracetamol inhibited only COX enzyme activity, caffeine also inhibited COX-2 protein synthesis. These results are compatible with the view that the clinical activity of paracetamol and caffeine is due to inhibition of COX. Furthermore, these results may help explain the clinical experience of an adjuvant analgesic effect of caffeine and paracetamol when combined with acetylsalicylic acid.
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Br J Clin Pharmacol · Aug 2000
A model for size and age changes in the pharmacokinetics of paracetamol in neonates, infants and children.
The aims of this study were to describe paracetamol pharmacokinetics in neonates and infants. ⋯ Total body clearance of paracetamol at birth is 62% and volume of distribution 174% that of older children. A target concentration above 10 mg l-1 in approximately 50% subjects can be achieved by a dose from 45 mg kg-1 day-1 at birth and up to 90 mg kg-1 day-1 in 5-year-old children. A reduced dose of 75 mg kg-1 day-1 in an 8-year-old child is sufficient because clearance is a nonlinear function of weight.