Articles: acetaminophen.
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Arch. Dis. Child. Fetal Neonatal Ed. · Nov 1998
Randomized Controlled Trial Clinical TrialRandomised controlled trial of paracetamol for heel prick pain in neonates.
To evaluate the effectiveness of paracetamol in decreasing the pain from heel prick. ⋯ Paracetamol is ineffective for decreasing the pain from heel prick in term neonates.
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Case Reports
[Severe hepatocellular damage after administration of paracetamol and chlorzoxazone in therapeutic dosage].
A 64 year old patient developed severe hepatocellular damage with jaundice and coagulopathy during ingestion of a combination of paracetamol and chlorzoxazone in therapeutic dosage. The risk factors for the development of liver cell necrosis following ingestion of paracetamol in therapeutic dosage are discussed. In particular in patients with risk factors (e.g. alcoholics and patients with heart failure) paracetamol-induced liver failure has to be considered in the presence of high transaminases, even when paracetamol was ingested in therapeutic dosage. Chlorzoxazone itself rarely can induce an idiosyncratic hepatocellular damage.
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J Paediatr Child Health · Oct 1998
Randomized Controlled Trial Comparative Study Clinical TrialRelative bioavailability and plasma paracetamol profiles of Panadol suppositories in children.
To determine the relative bioavailability and plasma paracetamol concentration profiles following administration of a proprietary formulation of paracetamol suppositories to postoperative children. ⋯ Absorption of paracetamol following rectal administration of Panadol suppositories to postoperative children is slower and reduced as compared to oral therapy. The hard wax and liquid filled products have similar absorption characteristics. The usually quoted antipyretic therapeutic range for paracetamol is 10-20 mg/L, although 5 mg/L may be effective. A single rectal dose of 25 mg/kg will obtain this lower concentration within 1 h of administration and maintain it for up to 6 h. When given in an appropriate dose for analgesia, maximum plasma paracetamol concentrations would be available in the immediate postoperative period if the rectal dose was given 2 h before the planned end of the procedure.