Articles: acetaminophen.
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Randomized Controlled Trial Comparative Study Clinical Trial
Acute red ear in children: controlled trial of non-antibiotic treatment in general practice.
To examine the efficacy and safety of conservative management of mild otitis media ("the acute red ear") in children. ⋯ Use of antibiotic improves short term outcome substantially and therefore continues to be an appropriate management policy.
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Clin. Pharmacol. Ther. · Sep 1991
Randomized Controlled Trial Clinical TrialHeadache pain model for assessing and comparing the efficacy of over-the-counter analgesic agents.
To refine the assessment of over-the-counter analgesic agents in the treatment of muscle-contraction headache, we designed a single-dose model with attention to specific methodologic features and two relevant assessments--the percentage of subjects who achieve complete relief and the time until pain is no longer experienced. Subjects were randomly assigned to receive a single dose of 1000 mg acetaminophen, 1000 mg aspirin with 64 mg caffeine, or placebo. ⋯ The aspirin-caffeine combination was rated higher than acetaminophen on all summary measurements, particularly SPID (p less than 0.05), with significantly more patients obtaining complete relief with aspirin-caffeine (p less than 0.01) than with acetaminophen. We conclude that this headache pain model can be used to demonstrate the efficacy of over-the-counter analgesic agents and to assess their relative efficacy.
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Riv Eur Sci Med Farmacol · Sep 1991
Gastric emptying of liquids and solids evaluated by acetaminophen test in diabetic patients with and without autonomic neuropathy.
A delayed gastric emptying of solids but not of liquids has been recorded in diabetic patients with autonomic neuropathy by radionuclide labelled test meals. Acetaminophen test (rate of acetaminophen absorption after ingestion of 1500 mg of the drug) has been previously validated for quantitative indirect measurement of gastric emptying. ⋯ After solid meal, the mean area under the plasma acetaminophen concentration-time curve was significantly lower in neuropathic diabetic patients vs control subjects (p less than 0.05), and the emptying index (peak time/peak plasma concentration ratio) was significantly higher in neuropathic diabetic patients vs non-neuropathic diabetic patients (p less than 0.01) and vs control subjects (p less than 0.05). These results confirm a delayed gastric emptying of solids but not of liquids in diabetic patients with autonomic neuropathy, and indicate that acetaminophen test may be proposed as simple, safe and noninvasive test for quantitative assessment of gastric emptying in diabetic patients.