Articles: acetaminophen.
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Pediatr Crit Care Me · Aug 2019
Comparative StudyAntipyretic Efficacy of Acetaminophen and Ibuprofen in Critically Ill Pediatric Patients.
To determine the antipyretic efficacy of acetaminophen (IV, enteral, rectal) and ibuprofen (enteral) in critically ill febrile pediatric patients. ⋯ Enteral ibuprofen was the most efficacious antipyretic and IV acetaminophen had the shortest time to defervescence.
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Randomized Controlled Trial
Intravenous vs Oral Acetaminophen for Analgesia After Cesarean Delivery: A Randomized Trial.
Examination of postoperative analgesia with intravenous and oral acetaminophen. ⋯ Intravenous acetaminophen did not reduce 24-hour opioid consumption or other outcomes compared with oral acetaminophen. Intravenous acetaminophen did decrease opioid consumption and pain scores compared with no acetaminophen.
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We explored how systematic reviews evaluated paracetamol and ibuprofen for treating pain in children, as these two non-opioid analgesics are well-established medicines included in most national essential medicines lists. ⋯ Evidence behind two analgesics-ibuprofen and paracetamol-that are well-established medicines for children in most countries appears limited, judging by the systematic reviews. The discrepancy between clinical use and the extensive evidence we reviewed may be a result of the selective criteria in the reviews examined. We need new, and better evidence syntheses supporting the use of these two medicines in wide indications regarding pain in children.
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Wien. Klin. Wochenschr. · Jul 2019
Incidence, etiology, predictors and outcomes of suspected drug hypersensitivity reactions in a tertiary care university hospital's emergency department : A retrospective study.
Allergic drug reactions are adverse drug reactions that result from a specific immunologic response to a medication. Considering the epidemiological and clinical importance of drug allergy, this retrospective analysis focused on drug hypersensitivity in a tertiary care university hospital emergency department (ED). ⋯ Drug hypersensitivity is a common reason for tertiary centre emergency admissions. This is the largest analysis of ED drug hypersensitivity admissions so far. Beta-lactams were identified as the leading cause of drug hypersensitivity requiring ED evaluation, which also explains the peak of drug hypersensitivity cases during winter months when the use of these medications is highest.
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Randomized Controlled Trial Comparative Study
Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial.
To compare the effect of premedication with 2 different doses of oral paracetamol to prevent pain at propofol intravenous injection. ⋯ A premedication with oral paracetamol can dose-dependently reduce pain at propofol intravenous injection. To avoid this common uncomfortable concern for the patients, this well-tolerated, available and cheap treatment appears as an option to be implemented in the current practice.