Articles: spider-venoms.
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Randomized Controlled Trial Multicenter Study Comparative Study
Randomized Controlled Trial of Intravenous Antivenom Versus Placebo for Latrodectism: The Second Redback Antivenom Evaluation (RAVE-II) Study.
Latrodectism is the most important spider envenomation syndrome worldwide. There remains considerable controversy over antivenom treatment. We aimed to investigate whether antivenom resulted in resolution of pain and systemic effects in patients with latrodectism who received standardized analgesia. ⋯ The addition of antivenom to standardized analgesia in patients with latrodectism did not significantly improve pain or systemic effects.
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Br J Clin Pharmacol · Jan 2008
Randomized Controlled Trial Multicenter Study Comparative StudyA comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom.
There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV). ⋯ RBS AV given by the intramuscular route is unlikely to be effective in the treatment of redback (widow) spider bite.
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Emerg Med Australas · Apr 2005
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialA double-blind, randomized trial of intravenous versus intramuscular antivenom for red-back spider envenoming.
To compare the efficacy of intravenous versus intramuscular antivenom (AV) in the treatment of Red-back spider (RBS) envenoming. ⋯ Red-back spider antivenom was initially effective by both i.m. and i.v. routes. The study generates the hypothesis that at 24 h, significantly more patients are pain-free with i.v. administration. Definitive recommendations on the optimal route of administration of RBS AV await the results of further studies.