Articles: pain.
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Anesthesia and analgesia · Nov 1983
Randomized Controlled Trial Clinical TrialEffect of transcutaneous nerve stimulation on postoperative pain after thoracotomy.
A prospective randomized double-blind study was undertaken to evaluate the efficacy of transcutaneous nerve stimulation (TNS) in relief of acute post-thoracotomy pain by comparing postoperative narcotic requirements in 22 patients having TNS and in 22 patients having sham electrical stimulation. All patients in both groups had intrathoracic malignancies. When TNS was used, 22.7% of the patients required no narcotics in the first 24 hr postoperatively. All patients having sham stimulation required postoperative narcotics.
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Ann R Coll Surg Engl · Nov 1983
Randomized Controlled Trial Clinical TrialPost-thoracotomy pain relief: combined use of cryoprobe and morphine infusion techniques.
In a reported study we found that freezing of the intercostal nerves under direct vision at thoracotomy provided better postoperative analgesia than im morphine on demand. Infusions of morphine were also more effective than when used by the intramuscular route. ⋯ Further studies were carried out to evaluate the benefit of combining 'cryoprobe' analgesia with infusions of morphine. The combined use of morphine infusion and a cryoprobe did not produce greater postoperative pain relief than the use of the cryoprobe alone with im morphine on demand.
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Randomized Controlled Trial Comparative Study Clinical Trial
The optimum concentration for epidural fentanyl. A randomised, double-blind comparison with and without 1:200 000 adrenaline.
A randomised, double-blind study comparing a variety of different concentrations of fentanyl with and without 1:200 000 adrenaline is described. It was shown that the quality and duration of analgesia with epidural fentanyl was concentration-dependent below 10 micrograms/ml, but that the addition of adrenaline abolished this phenomenon. The rate of failure to achieve any analgesia was very high with the more dilute solutions, but adrenaline reversed this problem. In general the incidences of side effects were related to the concentrations of fentanyl used and apart from itching, the incidences of these side effects were reduced by the addition of adrenaline.
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Clin. Pharmacol. Ther. · Oct 1983
Randomized Controlled Trial Comparative Study Clinical TrialCodeine and aspirin analgesia in postpartum uterine cramps: qualitative aspects of quantitative assessments.
The analgesic response to codeine of patients with postpartum uterine-cramp pain has recently met with controversy. To readdress this question, we conducted a new study comparing codeine sulfate, 60 mg (N = 32) and 120 mg (N = 31), with aspirin, 650 mg (N = 34), and placebo (N = 32) in hospitalized women with moderate or severe postpartum uterine cramps treated with single oral doses in a parallel, stratified, randomized, double-blind trial. Subjective reports were used as indices of response, and patients rated pain intensity, pain relief, and side effects at periodic, uniformly conducted interviews for 6 hr. ⋯ In contrast, in a subset of patients with mixed episiotomy-uterine pain (N = 73), 120 mg codeine showed good separation from placebo and compared favorably with aspirin. Codeine, 60 mg, showed a similar trend, and there was a strong suggestion of dose-dependent analgesia. Side effects were not remarkable except for dizziness and drowsiness after 120 mg codeine in all sets and subsets of patients.(ABSTRACT TRUNCATED AT 250 WORDS)
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Randomized Controlled Trial Clinical Trial
Analgesic effects of oral propiram fumarate, codeine sulfate and placebo in postoperative pain.
Our purpose was to evaluate the analgesic efficacy and safety of single oral doses of propiram fumarate 50 mg, codeine sulfate 60 mg and placebo in the relief of moderate to severe postoperative pain. One hundred and twenty patients completed a randomized, double-blind, single-dose, stratified, parallel-groups trial and were observed for either 4 or 6 hours. ⋯ Two adverse effects were attributed to propiram. Propiram fumarate 50 mg is an effective oral analgesic similar to codeine sulfate 60 mg, with the possibility of a longer duration of action.