Articles: pain.
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Randomized Controlled Trial Comparative Study Clinical Trial
Extradural versus intramuscular diamorphine. A controlled study of analgesic and adverse effects in the postoperative period.
The effects of diamorphine hydrochloride 0.1 mg/kg, given either extradurally or intramuscularly for postoperative analgesia were compared in two randomised double-blind studies involving 39 patients undergoing thoracotomy and major gynaecological surgery. Assessments were made at fixed intervals after the administration of diamorphine and consisted of the measurement of pain or analgesic effect. Segmental, sympathetic and any adverse effects were sought. ⋯ Extradural diamorphine provided safe and effective analgesia of rapid onset, with no specific undesirable side-effects. In both studies, analgesia was more prolonged following extradural administration. The relative proportion of spinal binding may be increased after extradural administration and this may be reflected in the prolonged analgesia observed.
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Arzneimittel Forsch · Jan 1983
Randomized Controlled Trial Comparative Study Clinical Trial[A controlled clinical single-dose comparative study of suprofen and diflunisal].
In a single-dose, double-blind randomized study, the analgesic efficacy of suprofen 200, suprofen (alpha-methyl-4-(2-thienylcarbonyl)-benzene acetic acid; Suprol) 400 mg and diflunisal 750 mg capsules was determined in comparison to placebo capsules. A total of 130 patients participated in the study, all of them requiring analgesic treatment on the first post-operative day following meniscectomy. ⋯ Despite great differences in dosage and half-life, the active test substances must be regarded as equipment. Side effects were reported by 2 patients each in the diflunisal 750 mg and the placebo group, and by 1 patient treated with suprofen 200 mg.
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Arzneimittel Forsch · Jan 1983
Randomized Controlled Trial Clinical Trial[Treatment of postoperative wound pain with suprofen].
The present randomized double-blind study was performed to investigate the analgesic effects of single doses of suprofen (alpha-methyl-4-(2-thienylcarbonyl)benzene acetic acid; Suprol) 200 mg, suprofen 400 mg paracetamol (APAP, acetaminophen) 650 mg, and combination suprofen 100 mg + APAP 650 mg versus placebo. The five treatment groups were homogeneous as to their demographic features and comprised 28--32 subjects each. Data for a total of 146 patients were evaluated. ⋯ Suprofen 200 mg ranked third. Statistical significance was only seen for the parameter pain intensity (SPID) on comparison of suprofen 100 mg + APAP 650 mg versus suprofen 200 mg. Side effects, homogeneously distributed over the treatment groups, were observed in four cases.
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Randomized Controlled Trial Comparative Study Clinical Trial
Postoperative analgesic effects of dexamethasone sodium phosphate in bunion surgery.
A double-blind study was performed to evaluate the postoperative analgesic effects of dexamethasone sodium phosphate. This steroid or normal saline was randomly injected immediately after surgery into both feet of 51 patients who had identical procedures performed on each foot for the correction of bunion deformities. ⋯ No complications were attributed to the steroid treatment. This study supports the use of dexamethasone sodium phosphate for postoperative analgesia.
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Randomized Controlled Trial Comparative Study Clinical Trial
Postoperative analgesia after circumcision in children.
The analgesic effects of systemically administered diamorphine, caudal analgesia with 0.5% bupivacaine plain and caudal analgesia with 0.5% bupivacaine plain to which morphine sulphate had been added were studied in boys undergoing circumcision. Postoperative analgesia was assessed using a linear analogue scale. The time interval between operation and subsequent analgesic administration and the number of analgesic doses in 24 h were compared. ⋯ The only detectable difference between the groups was a more rapid, but transient, recovery in the group receiving plain bupivacaine only. The frequency of vomiting was high in all groups. Caudal analgesia, with or without the addition of morphine, did not confer any advantage over injected diamorphine, and did not justify the extra time, risk and expense required to carry it out.