Articles: anesthetics.
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Randomized Controlled Trial Multicenter Study
Patient Priority Weighting of the Roland Morris Disability Questionnaire Does Not Change Results of the Lumbar Epidural Steroid Injections for Spinal Stenosis Trial.
Secondary analysis of lumbar epidural steroid injections for spinal stenosis randomized controlled trial data. ⋯ 2.
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Randomized Controlled Trial Multicenter Study
Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial.
This study evaluated subcutaneous injections of tetrodotoxin (TTX) for the treatment of moderate to severe, inadequately controlled cancer-related pain. ⋯ Although underpowered, this study demonstrates a clinically important analgesic signal. TTX may provide clinically meaningful analgesia for patients who have persistent moderate to severe cancer pain despite best analgesic care. This clinical study is registered with ClinicalTrials.gov (NCT00725114).
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Randomized Controlled Trial Multicenter Study Observational Study
A multicenter study of the analgesic effects of epidural chloroprocaine after lower limb orthopedic surgery.
To investigate the effects and optimal concentration of chloroprocaine for epidural analgesia after lower limb orthopedic surgery. ⋯ Epidural 1.2% chloroprocaine with 0.4μg/mL fentanyl could generate proper analgesic effects with little influence on mobility in patients undergoing lower limb orthopedic surgery. In addition, it could generate a good sense and movement separation, facilitating the early functional training.
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Anesthesia and analgesia · Dec 2016
Multicenter Study Observational StudyThoracic Paravertebral Nerve Blocks in Pediatric Patients: Safety and Clinical Experience.
Thoracic paravertebral nerve blocks (PVNBs) provide excellent analgesia for many surgeries. The primary aim was to estimate the complication rate, and secondary aims were to provide information on the potential clinical application of PVNBs. Data on 2390 PVNBs were collected. ⋯ There was 1 case of local anesthetic systemic toxicity for a major complication rate of 1 per 2390 PVNBs. The minor complication rate was 13.2%. We demonstrate a low risk of complications in pediatric patients receiving PVNBs for various surgeries.
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Randomized Controlled Trial Multicenter Study Comparative Study
Effect of endovenous lidocaine on analgesia and serum cytokines: double-blinded and randomized trial.
This trial aimed to compare postoperative analgesia, opioid consumption, duration of ileus and hospital stay, and cytokine levels in patients undergoing laparoscopic cholecystectomies who received intravenous lidocaine in comparison with a control group. ⋯ Intravenous lidocaine was not able to reduce postoperative pain, opioid consumption, and duration of ileus or length of hospital stay. However, its anti-inflammatory effect was noticeable.