Articles: anesthetics.
-
Anasth Intensivther Notfallmed · Feb 1982
[Principles of clinical pharmacokinetics in anaesthesiology (author's transl)].
The principles of clinical pharmacokinetics of intravenous and inhalation anaesthesia and the correlation with pharmacodynamics are reviewed with special reference to the commonly used anaesthetic agents. Pharmacokinetics is regarded mainly as an aid towards optimization of dosage. ⋯ Interindividual variations and biological disposition are not taken into account. The kinetic processes common to intravenous and inhalation anaesthesia are presented in the form of a multiexponential function for constant concentrations.
-
Halothane anesthesia administered to enzyme-induced animals in a hypoxic atmosphere consistently produced hepatic necrosis. Rats pretreated with phenobarbital were exposed to hypoxia at varying intervals after administration of halothane, enflurane, or isoflurane anesthesia. Anesthetics were administered at 1 MAC for 2 h. ⋯ The injury score of the enflurane and isoflurane groups were comparable to that of controls. We conclude that the potential for hypoxia-induced liver injury during recovery exists after halothane anesthesia. Neither enflurane nor isoflurane anesthesia produced significant hepatic injury in this model.
-
Ann Fr Anesth Reanim · Jan 1982
[Use of a ternary mixture of local anaesthetics for peridural anaesthesia during urgent caesarean operation. Report on 125 cases].
125 caesarean operations are conducted under peridural anaesthesia with a mixture of local anaesthetics containing per milliliter: 2.5 mg of bupivacaine, 2.5 mg of etidocaine, 12.5 mg of lidocaine, and 5.10(-6) epinephrine. The dose injected is 23.37 +/- 1.98 ml, the volume necessary for blocking a metamer being 1.18 +/- 0.10 ml/segment. ⋯ Apgar is 8.98 +/- 1.62 after one minute and 9.68 +/- 1.31 after five minutes. These results prove that under perfect circumstances it is possible to get out the baby in about ten minutes.