Articles: anesthetics.
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There have been few reports showing the relationship between blood pressure (BP) measured at clinics preoperatively and BP measured before anesthetic intubation/induction. The purpose of this study was to examine the relationship between BP measured at different times and settings preoperatively and BP measured before intubation/induction. ⋯ The preoperative systolic BP value measured during the examination by the anesthesiologist was found to be closely related to pre-intubation systolic BP measured in the operating room. Higher BP during the preoperative examination may be a result of anxiety-induced stress or white-coat hypertension. Measuring BP during the anesthesiologist's examination may be useful for predicting hypertension in the pre-intubation period.
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Although nitrous oxide is widely used for analgesia and anxiolysis, its use is under scrutiny because of concerns about its environmental impact and potential implications for mental health. This article discusses the advantages and disadvantages of this agent.
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Global Warming Potential vs Radiative Forcing
Global warming potential is "...the ratio of the cumulative radiative forcing (the energy being added to the planet, based on radiative efficiency and lifetime) over a time horizon from the instantaneous release of 1 kg of a given gas, such as desflurane, relative to that of 1 kg of carbon dioxide." A 100 year time horizon is commonly used as GWP100, reflecting the long lifetime of CO2, representing the warming potential of a single emission of a gas compared to the same mass of CO2. GWP is then used to derive CO2-equivalents.
Although GWP allows a simplistic comparison of greenhouse gases (eg. desflurane GWP 2530), it is misleading to use it to assess the climate impact of volatile anaesthetic agents primarily because of their short lifetimes, but also because "GWP does not consider the actual atmospheric abundance of a greenhouse gas, nor does it represent any of the physical complexity of the overall climate system..."
"Based on climate science, we assert that this is a physically unsound approach for determining the potential climate impact of volatile anaesthetic gases, and that it is the atmospheric concentration and radiative forcing of individual greenhouse gases that matter..." – Slingo & Slingo.
Instead climate scientists today prefer to use radiative forcing, "... the difference between the energy entering the planet and the energy leaving it..."
The percentage contribution of all volatile anaesthetic gases to radiative forcing is <0.01% compared to that from carbon dioxide. In comparison, the global emission reductions due to the COVID-19 lockdown were almost 1000x greater than the cumulative impact from anaesthetic volatile gases, and yet this reduction was undetectable above normal climate variability.
Atmospheric concentration (ppt) Atmospheric lifetime (y) (Effective) radiative forcing (Wm-2) Carbon dioxide 420,000,000 100+ 2.16 Methane 1,920,000 12.4 0.54 Nitrous oxide 336,000 123 0.21 Desflurane 0.37 14.1 0.00017 Sevoflurane 0.16 1.4 0.00003 Isoflurane 0.11 3.5 0.00006 "On the basis of GWP, anaesthetic gases appear to be very 'damaging'. However, this conclusion is scientifically unsound: their lifetimes are short; their emissions, accumulation and resulting atmospheric concentrations are minute; and their actual radiative forcing is vanishingly small."
More complexity...
Beyond the over-simplification of GWP and CO2e, Slingo & Slingo also explore the challenge in linking the minute radiative forcing of volatile anaesthetic gases to actual climate change and impact.
summary"...future warming will be determined by how successful we are in controlling our direct carbon dioxide emissions. ... While changing a vaporiser feels achievable and tangible, the scientific reality is inconsequential when we consider all the steps from GWP to climate impact. ... It is carbon dioxide emissions that will define our future, not the use of volatile anaesthetic agents."
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Reducing postoperative pain is still a tremendous challenge for perioperative clinicians. Lidocaine is a local anesthetic that belongs to the amide class and has anti-inflammatory, anti-hyperalgesic, and analgesic effects. Extensive research has been conducted to determine the optimal route for its administration. ⋯ This meta-analysis suggests that post-abdominal surgery intraperitoneal lidocaine administration has a better analgesic effect than intravenous lidocaine, with a lower pain score. However, intravenous lidocaine is more beneficial for gastrointestinal recovery after abdominal surgery.
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Anaesthetic practice contributes to climate change. Volatile capture technology, typically based on adsorption to a carbon- or silica-based substrate, has the potential to mitigate some of the harmful effects of using halogenated hydrocarbons. Anaesthetists have a professional responsibility to use anaesthetic agents which offer the greatest safety and clinical benefit with the lowest financial cost and environmental impacts. ⋯ Currently, there is no financial incentive for healthcare organisations to capture waste anaesthetic gases, and so the value of volatile capture technology requires quantification. System-level organisations, such as Greener NHS, are best positioned to commission such evaluations and make policy decisions to guide investment. Further research using volatile capture technology in real-world settings is necessary and we highlight some priority research questions to improve our understanding of the utility of this group of technologies.