Articles: blood-glucose-analysis.
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Diabetes Obes Metab · Jun 2009
Randomized Controlled Trial Multicenter Study Comparative StudyPatient-directed titration for achieving glycaemic goals using a once-daily basal insulin analogue: an assessment of two different fasting plasma glucose targets - the TITRATE study.
To compare efficacy and safety of two fasting plasma glucose (FPG) titration targets [4.4-6.1 mmol/l (80-110 mg/dl) and 3.9-5.0 mmol/l (70-90 mg/dl)] using a patient-directed, treat-to-target algorithm for once-daily basal insulin in insulin-naïve subjects with type 2 diabetes suboptimally treated with oral antidiabetes drugs (OADs). ⋯ The 3.9-5.0 mmol/l FPG target showed superior efficacy compared with the 4.4-6.1 mmol/l target, although both FPG titration targets resulted in substantial reductions of HbA(1c) in patients with type 2 diabetes using a patient-directed insulin titration algorithm. A majority of subjects in both titration groups achieved the ADA-recommended guideline of <7% HbA(1c) at the end of the study with low rates of hypoglycaemia. These data indicate that lowering the fasting glucose target using a self-directed titration algorithm with once-daily detemir is safe and increases the likelihood of achieving the target level of HbA(1c). Indeed, using this approach, a majority of patients can achieve an HbA(1c) of <7%.
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Critical care medicine · Feb 2009
Randomized Controlled Trial Multicenter StudyTight glycemic control may favor fibrinolysis in patients with sepsis.
To investigate whether tight glycemic control, in patients with sepsis, may restore a normal fibrinolysis by lowering plasminogen activator inhibitor (PAI)-1 levels. ⋯ Fibrinolysis inhibition, in severe sepsis/septic shock, seems to have a relevant pathogenetic role. In this context, tight glycemic control seems to reduce, with time, the fibrinolytic impairment and morbidity.
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Multicenter Study
Predictors of early seizure recurrence in patients admitted for seizures in the Emergency Department.
To determine the frequency of early seizure recurrence (ESR) and to evaluate predictors of ESR among patients attending the Emergency Department (ED) for seizure. ⋯ ESR is common in the ED setting. Alcohol consumption, capillary glucose, and abnormal neurological examination on arrival at the ED are associated with increased risk of ESR.
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J. Vet. Intern. Med. · Sep 2008
Multicenter StudyBlood glucose concentrations in critically ill neonatal foals.
Critical illness is associated with hyperglycemia in humans, and a greater degree and duration of hyperglycemia is associated with nonsurvival. Hypoglycemia is also seen in critically ill humans, and is associated with nonsurvival. This might also be true in the critically ill foal. ⋯ Derangements of blood glucose concentration are common in critically ill foals. Controlling blood glucose concentrations may therefore be beneficial in the critically ill neonatal foal, and this warrants further investigation.
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Intensive care medicine · Dec 2007
Randomized Controlled Trial Multicenter StudyStrict versus moderate glucose control after resuscitation from ventricular fibrillation.
Elevated blood glucose is associated with poor outcome in patients resuscitated from out-of-hospital cardiac arrest (OHCA). Our aim was to determine whether strict glucose control with intensive insulin treatment improves outcome of OHCA patients. ⋯ We found no additional survival benefit from strict glucose control compared with moderate glucose control with a target between 6 and 8 mmol/l in OHCA patients.