Articles: brain-injuries.
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Journal of neurotrauma · Nov 2007
Randomized Controlled TrialMultiplex assessment of cytokine and chemokine levels in cerebrospinal fluid following severe pediatric traumatic brain injury: effects of moderate hypothermia.
This study performed a comprehensive analysis of cerebrospinal fluid (CSF) cytokine levels after severe traumatic brain injury (TBI) in children using a multiplex bead array assay and to evaluate the effects of moderate hypothermia on cytokine levels. To this end, samples were collected during two prospective randomized controlled trials of therapeutic moderate hypothermia in pediatric TBI. Thirty-six children with severe TBI (Glasgow Coma Scale [GCS] score of
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J Neurosurg Anesthesiol · Oct 2007
Randomized Controlled TrialEffects of fentanyl and S(+)-ketamine on cerebral hemodynamics, gastrointestinal motility, and need of vasopressors in patients with intracranial pathologies: a pilot study.
In neurosurgical patients, opioids are administered to prevent secondary cerebral damage. Complications often related to the administration of opioids are a decrease in blood pressure affording the use of vasopressors and intestinal atonia. One alternative approach to opioids is the application of S(+)-ketamine. ⋯ There was no difference regarding ICP, CPP, and the time period until full enteral nutrition or first defecation between both groups. Patients who underwent analgesia with S(+)-ketamine showed a trend to a lower demand of norepinephrine compared with the fentanyl group. Our results indicate that S(+)-ketamine does not increase ICP and that its use in neurosurgical patients should not be discouraged on the basis of ICP-related concerns.
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Randomized Controlled Trial Comparative Study
Intensive insulin therapy versus conventional glycemic control in patients with acute neurological injury: a prospective controlled trial.
To compare intensive insulin therapy to conventional glycemic control in patients with acute neurological injury evaluating neurological outcome and morbimortality. ⋯ A less strict intensive insulin therapy can reduce hypoglycemia and still maintain its benefits.
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Journal of critical care · Sep 2007
Randomized Controlled TrialEffects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy.
We investigated the effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy (TBI). ⋯ Therapeutic mild hypothermia provides a promising way in the intensive care unit for patients with severe TBI after craniotomy.
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Randomized Controlled Trial Multicenter Study Comparative Study
Saline or albumin for fluid resuscitation in patients with traumatic brain injury.
In traumatic brain injury resuscitation with albumin is associated with a higher mortality than resuscitation with saline.
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