• J. Neurol. Neurosurg. Psychiatr. · Apr 2010

    Kinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke.

    • Esteban A Fridman, Marcos Crespo, Santiago Gomez Argüello, Lorena Degue, Mirta Villarreal, Stephan Bohlhalter, Lewis Wheaton, and Mark Hallett.
    • Neurorehabilitation Section and Spasticity Clinic, Neurology Department, Institute for Neurological Research, FLENI, Montaneses 2325, Buenos Aires C1428AQK, Argentina. efridman@fleni.org.ar
    • J. Neurol. Neurosurg. Psychiatr. 2010 Apr 1; 81 (4): 423-7.

    AbstractBackground Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.

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