• Wenfei Chen, Baolin Liu, Xianglin Li, Peiyuan Wang, and Bin Wang.
• College of Intelligence and Computing, Tianjin Key Laboratory of Cognitive Computing and Application, Tianjin University, Tianjin 300350, PR China.
• Neuroscience. 2020 Sep 1; 443: 140-147.

AbstractSpatial memory is an essential ability for living. Some studies have demonstrated the finding of sex differences in spatial memory. However, the results are diverse, ranging from "significant difference" to "no difference". In this study, we sought to determine the underlying sex differences observed during spatial memory by examining neurofunctional differences in the distinct cortical regions that lay within the spatial memory network. Functional magnetic resonance imaging (fMRI) was used to measure neural responses while healthy young adults were engaged in spatial memory tasks with different levels of memory load. Our results not only illustrate consistent spatial memory networks between the female and male groups but also find a functional interaction between sex and difficulty in left superior frontal gyrus (lSFG) during the encoding phase. In addition, sex divergences in spatial memory appear when task difficulty increases. In sum, our study supports the existence of sex differences in spatial memory and demonstrates the role of task-difficulty expressed in terms of spatial memory involvement.Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

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