• Paula Lunardi, Laura W de Souza, Bruna Dos Santos, Bruno Popik, and Lucas de Oliveira Alvares.
• Laboratório de Neurobiologia da Memória, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Neurociências, Universidade Federal do Rio Grande do Sul, Brazil.
• Neuroscience. 2020 Sep 15; 444: 33-42.

AbstractMost memories of life experiences will be forgotten or modified over time. Although several studies have investigated the processes underlying memory formation, the mechanisms behind memory updating and forgetting remain unclear. The endocannabinoid system has been shown to be closely involved in various memory processes such as consolidation, destabilization, and extinction. Here, we investigate the role of the endocannabinoid system in memory updating, behavioral flexibility, and forgetting. We found that the hippocampal infusion of CB1 antagonist prevented memory updating in the immediate footshock (context pre-exposure facilitation effect) and reversal learning. Also, CB1 antagonist accelerated forgetting in inhibitory avoidance. Thus, by indicating the important role played by the endocannabinoid system, our results extend current knowledge of the mechanisms underpinning memory updating and forgetting.Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

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