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Case Reports
Case report: simultaneous occurrence of multiple myeloma and non-Hodgkin lymphoma treated by CAR T therapy.
- Tongjuan Li, Jiaqi Tan, Liting Chen, Dong Kuang, Xia Mao, Yaoyao Lou, Jianfeng Zhou, and Xiaoxi Zhou.
- Department of Hematology.
- Medicine (Baltimore). 2020 Apr 1; 99 (16): e19739e19739.
RationaleB cell lymphoma can co-occur with multiple myeloma (MM), and the prognosis in this case is usually poor. We propose the combination of CD19-chimeric antigen receptor (CAR) T cells and BCMA-CAR T cells for the treatment of such patients to obtain a superior prognosis.Patient ConcernsWe present a 50-year-old patient with previous B cell lymphoma and subsequent multiple myeloma (MM).DiagnosisA diagnosis of B cell lymphoma and MM was made.InterventionsThe patient was treated with a combination of haploidentical CD19-chimeric antigen receptor (CAR) T cells and BCMA-CAR T cells.OutcomesAfter CAR T cell therapy, the monoclonal plasma cells in the bone marrow and M protein disappeared.LessonsThe combination therapy of CD19- and BCMA-CAR T cells is an effective measure to treat patients with concomitant or borderline cases of B cell lymphoma and MM.
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