• Bioinformatics · Oct 2019

    LIONS: analysis suite for detecting and quantifying transposable element initiated transcription from RNA-seq.

    • Artem Babaian, I Richard Thompson, Jake Lever, Liane Gagnier, Mohammad M Karimi, and Dixie L Mager.
    • Terry Fox Laboratory, BC Cancer, Vancouver, BC, Canada.
    • Bioinformatics. 2019 Oct 1; 35 (19): 3839-3841.

    SummaryTransposable elements (TEs) influence the evolution of novel transcriptional networks yet the specific and meaningful interpretation of how TE-derived transcriptional initiation contributes to the transcriptome has been marred by computational and methodological deficiencies. We developed LIONS for the analysis of RNA-seq data to specifically detect and quantify TE-initiated transcripts.Availability And ImplementationSource code, container, test data and instruction manual are freely available at www.github.com/ababaian/LIONS.Supplementary InformationSupplementary data are available at Bioinformatics online.© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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