Molecular layer interneurons: Key elements of cerebellar

Neuroscience · May 2021

Review

Molecular layer interneurons: Key elements of cerebellar network computation and behavior.

Molecular layer interneurons (MLIs) play an important role in cerebellar information processing by controlling Purkinje cell (PC) activity via inhibitory synaptic transmission. A local MLI network, constructed from both chemical and electrical synapses, is organized into spatially structured clusters that amplify feedforward and lateral inhibition to shape the temporal and spatial patterns of PC activity. Several recent in vivo studies indicate that such MLI circuits contribute not only to sensorimotor information processing, but also to precise motor coordination and cognitive processes. Here, we review current understanding of the organization of MLI circuits and their roles in the function of the mammalian cerebellum.

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- Jinsook Kim and George J Augustine.
- Lee Kong Chian School of Medicine Nanyang Technological University Singapore 308238, Singapore.
- Neuroscience. 2021 May 10; 462: 22-35.
AbstractMolecular layer interneurons (MLIs) play an important role in cerebellar information processing by controlling Purkinje cell (PC) activity via inhibitory synaptic transmission. A local MLI network, constructed from both chemical and electrical synapses, is organized into spatially structured clusters that amplify feedforward and lateral inhibition to shape the temporal and spatial patterns of PC activity. Several recent in vivo studies indicate that such MLI circuits contribute not only to sensorimotor information processing, but also to precise motor coordination and cognitive processes. Here, we review current understanding of the organization of MLI circuits and their roles in the function of the mammalian cerebellum.Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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Molecular layer interneurons: Key elements of cerebellar network computation and behavior.

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