• Neuroscience · May 2021

    Blockade Of Opiodergic System During Early Weaning Reverts Feeding Behavior Altered Patterns.

    • Larissa Cavalcanti do Amaral Almeida, Julliet Araújo de Souza, Tavares Gabriel Araújo GA Programa de Pós-graduação em nutrição (Federal University of Pernambuco) and Nantes Université, INRAE, UMR 1280, PhAN, Nantes, France., Matilde Cesiana da Silva, Silva Bruna Times BT Department of Nutrition (Federal University of Pernambuco), Brazil., Cruz Paula Luiza Menezes PLM Department of Nutrition (Federal University of Pernambuco), Brazil., Felipe Leitão de Souza, Elizabeth do Nascimento, Cavalcante Taisy Cinthia Ferro TCF Programa de pós-graduação em ciências da saúde - Faculdade de Ciências Médicas (Universidade de Pernambuco), Brazil., Amanda Alves Marcelino da Silva, and Sandra Lopes de Souza.
    • Programa de Pós-graduação em Neuropsiquiatria e Ciências do Comportamento (Federal University of Pernambuco), Brazil.
    • Neuroscience. 2021 May 21; 463: 254-263.

    AbstractAdverse experiences that occur during the early stages of life can have permanent repercussions in adulthood. Among these experiences, early weaning is one that can alter the molecular, cellular, and behavior patterns in later life. Centered on this fact, the objective of the current study was to evaluate the effect of early weaning at 15 days of life of Wistar rats on their feeding behavior and if the opioidergic system blockade would cause a reversal of these outcomes. Experimental groups were formed based on the weaning period of each litter. On postnatal day 15, the group D15 was weaned and, on postnatal day 30 (natural weaning), the group D30 was weaned. The rats weaned on postnatal day 15, and administered subcutaneous Naltrexone (3 mg/kg) were from group D15 + NTX. Those weaned at 15 days of age exhibited higher depressive-like behavior, lesser reactivity time to sucrose, and higher intake of palatable food than the control group. The Naltrexone administration was observed to reverse some outcomes, such as increasing the reactivity time to sucrose and decreasing the quantity of palatable food consumed, to levels similar to those of the control group. Together, the findings of the present study are indicative of the vital role played by the opioidergic system in inducing the changes noted in the eating behavior patterns during adulthood, post early weaning.Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.

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