• Neuroscience · May 2021

    Review

    Preventing the long-term effects of general anesthesia on the developing brain: how translational research can contribute.

    • Jean-Philippe Salaün, Nicolas Poirel, Souhayl Dahmani, Audrey Chagnot, Clément Gakuba, Carine Ali, Jean-Louis Gérard, Jean-Luc Hanouz, Gilles Orliaguet, and Denis Vivien.
    • Department of Anesthesiology and Critical Care Medicine, Caen University Hospital, Avenue de la Côte de Nacre, Caen 14033, France; Normandie Université, UNICAEN, INSERM, UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, Caen 14000, France. Electronic address: salaunjeanphilippe@gmail.com.
    • Neuroscience. 2021 May 1; 461: 172-179.

    AbstractIn 2017, the Food and Drug Administration published a safety recommendation to limit the exposure to general anesthesia as much as possible below the age of three. Indeed, several preclinical and clinical studies have questioned the possible toxicity of general anesthesia on the developing brain. Since then, recent clinical studies tried to mitigate this alarming issue. What is true, what is false? Contrary to some perceptions, the debate is not over yet. Only stronger translational research will allow scientists to provide concrete answers to this public health issue. In this review, we will provide and discuss the more recent data in this field, including the point of view of preclinical researchers, neuropsychologists and pediatric anesthesiologists. Through translational research, preclinical researchers have more than ever a role to play to better understand and identify long-term effects of general anesthesia for pediatric surgery on brain development in order to minimize it.Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.

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